AJI-214

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AJI-214 Suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 13816613772
Email: huahero21@sina.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
AJI-214 Basic information
Product Name:AJI-214
Synonyms:AJI-214;Benzamide, 4-[[4-[(2-chlorophenyl)amino]-5-fluoro-2-pyrimidinyl]amino]-
CAS:1395886-20-0
MF:C17H13ClFN5O
MW:357.77
EINECS:
Product Categories:
Mol File:1395886-20-0.mol
AJI-214 Structure
AJI-214 Chemical Properties
Melting point 250-252 °C
Boiling point 562.434±60.00 °C(Press: 760.00 Torr)(predicted)
density 1.473±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka16.133±0.50(predicted)
Safety Information
MSDS Information
AJI-214 Usage And Synthesis
UsesAJI-214 is a dual-target inhibitor of Aurora kinase A and JAK2. AJI-214 directly blocks Aurora kinase A to inhibit T cell mitotic progression and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-214 can be used in studies on regulating immune responses and preventing graft-versus-host disease (GVHD)[1].
References[1] Betts, et al. "Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining Treg and antitumor CTL function." Science translational medicine 9.372 (2017): eaai8269. DOI:10.1126/scitranslmed.aai8269
AJI-214 Preparation Products And Raw materials
Tag:AJI-214(1395886-20-0) Related Product Information
NA JAK1 Protein, HUMAN (P. PASTORIS, HIS)