|
|
| | CCT070535 Basic information |
| Product Name: | CCT070535 | | Synonyms: | CCT070535;Pyrimido[1,2-b]pyridazin-5-ium, 7-chloro-1-(4-chlorophenyl)-1,2-dihydro-4-hydroxy-2-oxo-3-(phenylmethyl)-, inner salt | | CAS: | 485319-41-3 | | MF: | C20H13Cl2N3O2 | | MW: | 398.24 | | EINECS: | | | Product Categories: | | | Mol File: | 485319-41-3.mol |  |
| | CCT070535 Chemical Properties |
| | CCT070535 Usage And Synthesis |
| Uses | CCT070535 blocks TCF-dependent transcription at the TCF level, with GI50 values of 17.6 μM, 11.1 μM, 11.8 μM and 13.4 μM in HT29 (APC mutant), HCT116 (oncogenic β-catenin), SW480 (APC mutant) and SNU475 (Axin mutant) cells, respectively[1]. | | References | [1] Kenneth Ewan, et al. A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res. 2010 Jul 15;70(14):5963-73. DOI:10.1158/0008-5472.CAN-10-1028 |
| | CCT070535 Preparation Products And Raw materials |
|