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| | 2-Morpholinopyrimidin-5-ylboronic acid Basic information |
| Product Name: | 2-Morpholinopyrimidin-5-ylboronic acid | | Synonyms: | 2-morpholinopyrimidin-5-ylboronic acid;[2-(4-Morpholinyl)-5-pyrimidinyl]boronic acid;2-Morpholinopyrimidine-5-boronic acid;Boronic acid,B-[2-(4-morpholinyl)-5-pyrimidinyl]-;2-(Morpholine-4-yl)pyrimidine-5-boronic acid;2-morpholino-5-pyrimidineboronic acid;2-Morpholinopyrimidin-5-ylboronic acid 95%;(2-(Morpholin-4-yl)pyrimidin-5-yl)boronic | | CAS: | 870521-33-8 | | MF: | C8H12BN3O3 | | MW: | 209.01 | | EINECS: | | | Product Categories: | | | Mol File: | 870521-33-8.mol |  |
| | 2-Morpholinopyrimidin-5-ylboronic acid Chemical Properties |
| Boiling point | 484.0±55.0 °C(Predicted) | | density | 1.37 | | storage temp. | Inert atmosphere,2-8°C | | pka | 3.02±0.19(Predicted) | | form | solid | | Appearance | White to yellow Solid | | InChI | 1S/C8H12BN3O3/c13-9(14)7-5-10-8(11-6-7)12-1-3-15-4-2-12/h5-6,13-14H,1-4H2 | | InChIKey | KFYQOIHLZBDFBU-UHFFFAOYSA-N | | SMILES | OB(O)c1cnc(nc1)N2CCOCC2 |
| WGK Germany | WGK 3 | | HS Code | 2934999090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 2-Morpholinopyrimidin-5-ylboronic acid Usage And Synthesis |
| Synthesis | The reaction was carried out with 2-chloropyrimidin-5-ylboronic acid (1 g, 6.32 mmol), morpholine (2.19 mL, 25.26 mmol) and triethylamine (0.88 mL, 6.32 mmol) in ethanol (25 mL) with stirring for 1 hour at 20 °C. After completion of the reaction, water (50 mL) was slowly added to the reaction mixture. The resulting precipitate was collected by filtration and washed with water to finally obtain 2-morpholinopyrimidin-5-ylboronic acid (950 mg, 70% yield) as a milky white solid. The NMR hydrogen spectrum (250 MHz, DMSO-d6) data were as follows: δ 8.63 (s, 2H), 8.05 (s, 2H), 3.68 (ddd, J=23.4,5.7,3.9Hz, 8H). | | References | [1] Patent: WO2015/86506, 2015, A1. Location in patent: Page/Page column 131
[2] Patent: WO2015/86512, 2015, A1. Location in patent: Page/Page column 102
[3] Patent: WO2015/86527, 2015, A1. Location in patent: Page/Page column 114; 115
[4] Patent: WO2015/86526, 2015, A1. Location in patent: Page/Page column 147
[5] Patent: WO2015/86525, 2015, A1. Location in patent: Page/Page column 121; 122 |
| | 2-Morpholinopyrimidin-5-ylboronic acid Preparation Products And Raw materials |
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