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phenanthridin-6-amine manufacturers
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| | phenanthridin-6-amine Basic information |
| Product Name: | phenanthridin-6-amine | | Synonyms: | phenanthridin-6-amine;6-Phenanthridinamine;Phenanthridine-6-amine;6-Aminophenanthridine;6-Amino-phenanthridine;6-Aminophenanthridine >=98% (HPLC);6Aminophenanthridine,6 Aminophenanthridine | | CAS: | 832-68-8 | | MF: | C13H10N2 | | MW: | 194.23 | | EINECS: | | | Product Categories: | | | Mol File: | 832-68-8.mol |  |
| | phenanthridin-6-amine Chemical Properties |
| Melting point | 194-195 °C(Solv: benzene (71-43-2)) | | Boiling point | 406.4±20.0 °C(Predicted) | | density | 1.268±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble20mg/mL, clear | | form | powder | | pka | 6.88±0.10(Predicted) | | color | white to brown | | InChI | 1S/C13H10N2/c14-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)15-13/h1-8H,(H2,14,15) | | InChIKey | FVCXJXKLDUJOFA-UHFFFAOYSA-N | | SMILES | Nc1nc2c(c3c1cccc3)cccc2 |
| Hazard Codes | T,Xi | | Risk Statements | 25-36 | | Safety Statements | 26-45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Irrit. 2 |
| | phenanthridin-6-amine Usage And Synthesis |
| Uses | 6-Aminophenanthridine inhibits the protein folding activity of the ribosome (PFAR). 6-Aminophenanthridine competitively occludes the protein substrates from binding to rRNA and thereby inhibits PFAR[1]. | | Biological Activity | 6-Aminophenanthridine selectively inhibits protein folding activity of the ribosome (PFAR). Apparently 6-Aminophenanthridine interacts with the ribosome domain V rRNA and the protein substrate. 6-Aminophenanthridine is an antiprion compound th at promotes mammalian prion clearance. | | storage | +4°C | | References | [1] Pang Y, et al. The antiprion compound 6-aminophenanthridine inhibits the protein folding activity of the ribosome by direct competition. J Biol Chem. 2013;288(26):19081-19089. DOI:10.1074/jbc.M113.466748 |
| | phenanthridin-6-amine Preparation Products And Raw materials |
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