| Company Name: |
TargetMol |
| Tel: |
400-821-0310 15002144251 |
| Email: |
xuexiang.shao@tsbiochem.com |
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| | FerroLOXIN-1 Basic information |
| Product Name: | FerroLOXIN-1 | | Synonyms: | FerroLOXIN-1;1H-Imidazol-2-amine, 1-(3-fluorophenyl)-N-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]-4-phenyl- | | CAS: | 2773428-48-9 | | MF: | C23H16F5N3 | | MW: | 429.39 | | EINECS: | | | Product Categories: | | | Mol File: | 2773428-48-9.mol |  |
| | FerroLOXIN-1 Chemical Properties |
| Boiling point | 556.620±60.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.307±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | -10 to -25°C | | solubility | DMSO: 2mg/mL, clear (Warmed) | | form | powder | | pka | 7.141±0.10(predicted) | | color | white to beige |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | FerroLOXIN-1 Usage And Synthesis |
| Uses | FerroLOXIN-1 is a potent inhibitor of 15LOX-2 that selectively blocked production of pro-ferroptotic HOO-ETE-PE and protected against RSL3-induced ferroptosis. FerroLOXIN-1 closely interacted therein with 15LOX-2 only, and in particular with Y154, N155, W158[1]. | | Biological Activity | 15LOX/PEBP1 catalytic complex inhibitor th at prevents cell death by ferroptosis, but not necroptosis, pyroptosis, or apoptosis.
FerroLOXIN-1 is a ferroptosis inhibitor th at selectively targets the 15LOX/PEBP1 catalytic complex without affecting the biosynthesis of pro-/anti-inflammatory lipid mediators. FerroLOXIN-1 prevents 0.5 μM GPX4 inhibitor RSL3-induced ferroptosis in HBE cell cultures (IC50 = 84 nM post 20h RSL3 treatment) and rescues mice from total body irradiation (TBI)-induced death in vivo (Cpd administered via 25 mg/kg ip. 20h post 9.25Gy irradiation; survival on day 27 = 75% vs. 0% on day 19 of untreated control). FerroLOXIN-1 does not exert its efficacy via radical scavenging or iron-chelating activity, nor does it prevent cell death by necroptosis, pyroptosis, or apoptosis. | | IC 50 | 5-LOX | | References | [1] Dong J, et al. Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy. Angew Chem Int Ed Engl. 2023 May 22;62(22):e202303818. |
| | FerroLOXIN-1 Preparation Products And Raw materials |
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