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| | FcγRI/CD64 Rabbit Monoclonal Antibody (Clone 027) Basic information |
| | FcγRI/CD64 Rabbit Monoclonal Antibody (Clone 027) Chemical Properties |
| | FcγRI/CD64 Rabbit Monoclonal Antibody (Clone 027) Usage And Synthesis |
| Description | CD64, also known as high-affinity immunoglobulin γ receptor I (FcγRI), is a transmembrane glycoprotein that binds the Fc region of IgG.1 It is composed of a ligand-binding α-chain, which contains three extracellular Ig-like domains, a transmembrane region, and a cytoplasmic domain, and two γ-chains, which contain immunoreceptor tyrosine-based activation motifs (ITAMs) that mediate signal transduction.2,3,4 CD64 is constitutively expressed in myeloid cells, including monocytes and macrophages, but can be induced in neutrophils in response to IFN-γ or G-CSF.5,3 It is involved in phagocytosis, cytokine release, antibody-dependent cell-mediated cytotoxicity (ADCC), and antigen presentation to primed T cells.1,6 Mouse CD64 selectively forms immune complexes with IgG2a, whereas human CD64 forms immune complexes with IgG1, IgG3, and IgG4.1,7 Knockout of Fcgr1, the gene encoding CD64, inhibits clearance of B. pertussis infection in mice.1 Increased serum levels of CD64 are associated with sepsis.8 Cayman’s FcγRI/CD64 Rabbit Monoclonal Antibody (Clone 027) can be used for flow cytometry (FC), immunocytochemistry (ICC), and immunofluorescence (IF) applications.WARNING This product is not for human or veterinary use. |
| | FcγRI/CD64 Rabbit Monoclonal Antibody (Clone 027) Preparation Products And Raw materials |
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