SARS-CoV-2 Spike Glycoprotein S1 Subunit Neutralizing Monoclonal Antibody (Clone 43)

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SARS-CoV-2 Spike Glycoprotein S1 Subunit Neutralizing Monoclonal Antibody (Clone 43) Basic information
Product Name:SARS-CoV-2 Spike Glycoprotein S1 Subunit Neutralizing Monoclonal Antibody (Clone 43)
Synonyms:SARS-CoV-2 Spike Glycoprotein S1 Subunit Neutralizing Monoclonal Antibody (Clone 43)
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SARS-CoV-2 Spike Glycoprotein S1 Subunit Neutralizing Monoclonal Antibody (Clone 43) Structure
SARS-CoV-2 Spike Glycoprotein S1 Subunit Neutralizing Monoclonal Antibody (Clone 43) Chemical Properties
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SARS-CoV-2 Spike Glycoprotein S1 Subunit Neutralizing Monoclonal Antibody (Clone 43) Usage And Synthesis
DescriptionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive-stranded RNA virus, a member of the Betacoronavirus genus, and the causative agent of COVID-19.1,2,3,4,5 The SARS-CoV-2 spike glycoprotein, also known as the surface glycoprotein, is located on the outer envelope of the virion.1 It is composed of an S1 and S2 subunit divided by a furin S-cleavage site not found in other SARS-CoVs.6,7 The S1 subunit contains the receptor-binding domain (RBD), which binds to the carboxypeptidase angiotensin-converting enzyme 2 (ACE2), and the S1 and S2 subunits are cleaved by the protease TMPRSS2 to facilitate viral fusion with the host cell membrane.8,9,10 In this way, ACE2 acts as the functional receptor for SARS-CoV-2. The SARS-CoV-2 spike glycoprotein S1 subunit induces inflammatory gene expression in the frontal cortex, hippocampus, and hypothalamus, as well as activates toll-like receptor 2 (TLR2) and TLR4 signaling and increases social avoidance in the juvenile social exploration test in rats.11 SARS-CoV-2 infection can result in the production of neutralizing antibodies, which bind to the SARS-CoV-2 spike RBD preventing further viral entry and infection, starting approximately 4-10 days after symptom onset.12,13 Cayman’s SARS-CoV-2 Spike Glycoprotein S1 Subunit Neutralizing Monoclonal Antibody (Clone 43) disrupts the spike glycoprotein S1 subunit-ACE2 interaction and can be used for ELISA, flow cytometry (FC), and immunohistochemistry (IHC; paraffin) applications, as well as microneutralization (MN) assays.WARNING This product is not for human or veterinary use.
SARS-CoV-2 Spike Glycoprotein S1 Subunit Neutralizing Monoclonal Antibody (Clone 43) Preparation Products And Raw materials
Tag:SARS-CoV-2 Spike Glycoprotein S1 Subunit Neutralizing Monoclonal Antibody (Clone 43) Related Product Information
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