Guanosine-5'-O-(2-thiodiphosphate) (sodium salt)

Request For Quotation
Guanosine-5'-O-(2-thiodiphosphate) (sodium salt) Suppliers list
Company Name: Shanghai meikai technology co., ltd  
Tel: 021-68689288 15300790979
Email: info@mkbio.com.cn
Guanosine-5'-O-(2-thiodiphosphate) (sodium salt) Basic information
Product Name:Guanosine-5'-O-(2-thiodiphosphate) (sodium salt)
Synonyms:Guanosine-5'-O-(2-thiodiphosphate) (sodium salt);Guanosine-5'-O-(2-thiodiphosphate) (sodium salt)
CAS:
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
Guanosine-5'-O-(2-thiodiphosphate) (sodium salt) Structure
Guanosine-5'-O-(2-thiodiphosphate) (sodium salt) Chemical Properties
solubility Water: Soluble
Safety Information
MSDS Information
Guanosine-5'-O-(2-thiodiphosphate) (sodium salt) Usage And Synthesis
DescriptionGuanosine-5'-O-(2-thiodiphosphate) is a non-hydrolyzable derivative of GDP (Item No. 31704) and an inhibitor of adenylyl cyclase (AC; Ki = 600 nM).1 It is also a partial activator of AC when GTP is absent in rat cerebral cortex membranes (EC50 = 400 nM).2 Guanosine-5'-O-(2-thiodiphosphate) (1 µM) prevents norepinephrine-induced nitric oxide (NO) release in cardiac ventricular myocytes.3 It reduces female opossum urine-induced firing frequency of olfactory mitral/tufted neuronal cells in male opossums when administered at a concentration of 100 µM.4WARNING This product is not for human or veterinary use.
References[1] M. SVOBODA . Guanosine 5′-O-(2-thiodiphosphate) as a competitive inhibitor of GTP in hormone or cholera toxin-stimulated pancreatic adenylate cyclase[J]. FEBS Letters, 1980, 109 2: Pages 275-279. DOI: 10.1016/0014-5793(80)81104-5
[2] M.M. RASENICK  N. W  J M Hughes. Guanosine-5′-O-thiodiphosphate functions as a partial agonist for the receptor-independent stimulation of neural adenylate cyclase[J]. Brain Research, 1989, 488 1: Pages 105-113. DOI: 10.1016/0006-8993(89)90698-7
[3] A J KANAI. Beta-adrenergic regulation of constitutive nitric oxide synthase in cardiac myocytes.[J]. American Journal of Physiology, 1997, 273 4: C1371-7. DOI: 10.1152/ajpcell.1997.273.4.c1371
[4] JING-JI ZHANG  Mimi H  Guang Zhe Huang. Firing properties of accessory olfactory bulb mitral/tufted cells in response to urine delivered to the vomeronasal organ of gray short-tailed opossums.[J]. Chemical Senses, 2007, 32 4: 355-360. DOI: 10.1093/chemse/bjm005
Guanosine-5'-O-(2-thiodiphosphate) (sodium salt) Preparation Products And Raw materials
Tag:Guanosine-5'-O-(2-thiodiphosphate) (sodium salt) Related Product Information
Rp-Guanosine-5'-O-(1-thiodiphosphate) (sodium salt) Adenosine, 5′→P′-ester with [P′(R)]-thiodiphosphoric acid ((HO)2P(O)OP(O)(OH)(SH)), sodium salt (1:3) Adenosine-5'-O-(2-thiodiphosphate) (sodium salt) Adenosine, 5′→P′-ester with [P′(S)]-thiodiphosphoric acid ((HO)2P(O)OP(O)(OH)(SH)), sodium salt (1:3) Sp-Guanosine-5'-O-(1-thiodiphosphate) (sodium salt)