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| | 4-(2-AMINOETHYL)TETRAHYDROPYRAN Basic information |
| Product Name: | 4-(2-AMINOETHYL)TETRAHYDROPYRAN | | Synonyms: | 2-(TETRAHYDRO-PYRAN-4-YL)-ETHYLAMINE;4-(2-Aminoethyl)tetrahydro-2H-pyran;4-(2-Aminoethyl)tetrahydropyrane;4-(2-Aminoethyl)tetrahydro-2H-pyran 97%;4-(2-AMINOETHYL)TETRAHYDROPYRAN;4-(2-Aminoethyl)tetrahydropyran ,97%;4-Aminoethyl-tetrahydropyrane;4-(AMinoethyl)tetrahydrop... | | CAS: | 65412-03-5 | | MF: | C7H15NO | | MW: | 129.2 | | EINECS: | 145-589-6 | | Product Categories: | Amines;blocks;Heterocycles | | Mol File: | 65412-03-5.mol |  |
| | 4-(2-AMINOETHYL)TETRAHYDROPYRAN Chemical Properties |
| Boiling point | 88-89°C 13mm | | density | 0.931±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Oil | | pka | 10.34±0.10(Predicted) | | color | Clear Colourless | | InChI | 1S/C7H15NO/c8-4-1-7-2-5-9-6-3-7/h7H,1-6,8H2 | | InChIKey | BZMADPOGYCRPAI-UHFFFAOYSA-N | | SMILES | NCCC1CCOCC1 | | CAS DataBase Reference | 65412-03-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38-41-37/38 | | Safety Statements | 26-36/37/39-39-36 | | WGK Germany | WGK 3 | | Hazard Note | Irritant/Keep Cold | | HS Code | 29339900 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 4-(2-AMINOETHYL)TETRAHYDROPYRAN Usage And Synthesis |
| Chemical Properties | Clear colorless liquid | | Uses | 4-(2-Aminoethyl)tetrahydropyran is a useful pharmaceutical intermediate. | | Synthesis | General procedure for the synthesis of 4-(2-aminoethyl)tetrahydropyran from 4-cyanomethyltetrahydropyran: (tetrahydro-4-pyranyl)-acetonitrile (75 g, 0.60 mol), Pd/C catalyst (2.5 g), and ethanol (400 mL) were added to a hydrogenation reactor. The air in the reactor was replaced with hydrogen three times, and then the reaction was stirred at 25 °C and 1 MPa hydrogen pressure for 12 hours. After completion of the reaction, the catalyst was removed by filtration, and the filtrate was transferred to a rotary evaporator and distilled under reduced pressure to remove the solvent to give 65.8 g (0.51 mol) of 4-(2-aminoethyl)tetrahydropyran as an oil. | | References | [1] Patent: CN106083787, 2016, A. Location in patent: Paragraph 0011; 0018; 0019; 0020; 0021; 0022; 0023 |
| | 4-(2-AMINOETHYL)TETRAHYDROPYRAN Preparation Products And Raw materials |
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