2-Amino-4-methylbenzonitrile

2-Amino-4-methylbenzonitrile Suppliers list

Company Name:	TCI (Shanghai) Development Co., Ltd.
Tel:	021-67121386
Email:	Sales-CN@TCIchemicals.com

2-Amino-4-methylbenzonitrile manufacturers

2-Amino-4-methylbenzonitrile Basic information

Product Name:	2-Amino-4-methylbenzonitrile
Synonyms:	4-Methyl-2-aminobenzonitrile;2-AMINO-4-METHYLBENZONITRILE;2-Cyano-5-methylaniline, 3-Amino-4-cyanotoluene, 6-Cyano-m-toluidine;2-Cyano-5-methylaniline, 3-Amino-4-cyanotoluene;Benzonitrile, 2-aMino-4-Methyl-;3-Amino-4-cyanotoluene 2-Cyano-5-methylaniline 6-Cyano-m-toluidine;2-Amino-4-methylbenzonitrile >;2-Cyano-5-methylaniline
CAS:	26830-96-6
MF:	C8H8N2
MW:	132.16
EINECS:	248-020-0
Product Categories:	Aromatic Nitriles;Amines;Phenyls & Phenyl-Het;Nitrile;Phenyls & Phenyl-Het;C8 to C9;Cyanides/Nitriles;Nitrogen Compounds
Mol File:	26830-96-6.mol

2-Amino-4-methylbenzonitrile Chemical Properties

Melting point	92-95 °C (lit.)
Boiling point	150-152 °C(Press: 15 Torr)
density	1.10±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	soluble in Methanol
pka	1.94±0.10(Predicted)
form	Powder
color	Light yellow to Yellow to Orange
InChI	1S/C8H8N2/c1-6-2-3-7(5-9)8(10)4-6/h2-4H,10H2,1H3
InChIKey	LGNVAEIITHYWCG-UHFFFAOYSA-N
SMILES	Cc1ccc(C#N)c(N)c1
CAS DataBase Reference	26830-96-6(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn,T
Risk Statements	20/21/22-36/37/38
Safety Statements	26-36-36/37
RIDADR	3439
WGK Germany	3
Hazard Note	Toxic
HazardClass	6.1
PackingGroup	III
HS Code	29269090
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

2-Amino-4-methylbenzonitrile Usage And Synthesis

Chemical Properties	white to light yellow crystal powder
Uses	2-Amino-4-methylbenzonitrile was used in the synthesis of: 7-methyl-4-(phenylamino)quinazoline-2(1H)-selone racemic aminoquinolines, potential acetylcholinesterase (AChE) inhibitors
Synthesis	26830-95-5 26830-96-6 a) Synthesis of 2-amino-4-methylbenzonitrile 4-Methyl-2-nitrobenzonitrile (4.9 g, 30 mmol) was mixed with 10% palladium-carbon catalyst (500 mg) in 1,4-dioxane (60 mL), and the reaction was stirred overnight under a hydrogen atmosphere (balloon pressurized). Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under reduced pressure to give the crude product. The crude product was further purified by fast column chromatography (eluent: dichloromethane) to afford 2-amino-4-methylbenzonitrile as a light yellow solid (3.3 g, 83% yield). 1H-NMR (300 MHz, CDCl3) δ 7.26 (d, J = 8.3 Hz, 1H), 6.56 (s, 1H), 6.55 (s, 1H), 4.32 (br s, 2H), 2.29 (s, 3H).
References	[1] Chemical Communications, 2011, vol. 47, # 31, p. 8808 - 8810 [2] Journal of the Chemical Society, Perkin Transactions 2, 2001, # 2, p. 214 - 228 [3] Patent: US5891909, 1999, A [4] Patent: EP906091, 2006, B1. Location in patent: Page/Page column 46 [5] Journal fuer Praktische Chemie (Leipzig), 1889, vol. <2> 40, p. 12

2-Amino-4-methylbenzonitrile Preparation Products And Raw materials

Raw materials	Ethanol-->Acetic acid-->N,N-Dimethylformamide-->Iron-->Copper(I) Cyanide-->4-Chloro-3-nitrotoluene-->4-Methyl-2-nitrobenzonitrile-->1,4-Dioxane-->Hydrogen
Preparation Products	2-Amino-4-methylbenzoic acid-->2-Amino-4-methylbenzamide-->7-methylquinazolin-4-amine-->7-Methylquinazoline-2,4(1H,3H)-dione

Tag:2-Amino-4-methylbenzonitrile(26830-96-6) Related Product Information

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