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| | [DPRO5] CORTICOTROPIN RELEASING FACTOR, HUMAN, RAT Basic information |
| Product Name: | [DPRO5] CORTICOTROPIN RELEASING FACTOR, HUMAN, RAT | | Synonyms: | [DPRO5] CORTICOTROPIN RELEASING FACTOR, HUMAN, RAT;[DPRO5] CRF, HUMAN, RAT;SER-GLU-GLU-PRO-DPRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-MET-GLU-ILE-ILE-NH2: SEEP-DP-ISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII-NH2 | | CAS: | 195628-97-8 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![[DPRO5] CORTICOTROPIN RELEASING FACTOR, HUMAN, RAT Structure]() |
| | [DPRO5] CORTICOTROPIN RELEASING FACTOR, HUMAN, RAT Chemical Properties |
| | [DPRO5] CORTICOTROPIN RELEASING FACTOR, HUMAN, RAT Usage And Synthesis |
| Uses | [DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat[1]. | | in vivo | [DPro5] Corticotropin Releasing Factor, human, rat (0.01-1 μg; i.c.v.; single dose) doesn’t induce the typical anxiogenic effect, but produces a nonspecific suppression of behavior in Sprague-Dowley rats. And [DPro5] Corticotropin Releasing Factor, human, rat also enhances the short-term memory to a maximum degree and prevented the memory loss induced by diazepam[1].
| Animal Model: | Sprague-Dowley rats[1] | | Dosage: | 0.01-1 μg | | Administration: | Intracerebroventricular injection; single dose | | Result: | Decreased the number of visits into the light box in the dark-light test. |
| | References | [1] Shabanov PD, et al. [Anxiogenic and mnestic effects of corticoliberin and its analogs introduced into the brain ventriculi of rats]. Eksp Klin Farmakol. 2006 Nov-Dec;69(6):3-8. Russian. PMID:17209454
[2] Rebaudo R, et al. Electrophysiological effects of sustained delivery of CRF and its receptor agonists in hippocampal slices. Brain Res. 2001 Dec 13;922(1):112-7. DOI:10.1016/s0006-8993(01)03160-2 |
| | [DPRO5] CORTICOTROPIN RELEASING FACTOR, HUMAN, RAT Preparation Products And Raw materials |
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