QX-314
| 中文名称 | QX-314 |
|---|---|
| 中文同义词 | 化合物QX-314 CHLORIDE;QX-314氯化物(N-乙基乙卡因氯化物);QX-314 CHLORIDE (N-ETHYLLIDOCAINE CHLORIDE),NA+ CHANNEL BLOCKER;QX-314 CHLORIDE (N-ETHYLLIDOCAINE CHLORIDE) (MM/ML),NA+ CHANNEL BLOCKER;化合物QX-314 CHLORIDE,10 MM DMSO 溶液 |
| 英文名称 | QX 314 chloride |
| 英文同义词 | QX 314 CHLORIDE;N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE;2-(2,6-Dimethylphenylamino)-N,N,N-triethyl-2-oxoethanaminium chloride;[2-(2,6-dimethylanilino)-2-keto-ethyl]-triethyl-ammonium chloride;[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium chloride;[2-[(2,6-dimethylphenyl)amino]-2-oxo-ethyl]-triethyl-azanium chloride;Lidocaine N-ethyl chloride;N-Ethyllidocaine chloride |
| CAS号 | 5369-03-9 |
| 分子式 | C16H27ClN2O |
| 分子量 | 298.85 |
| EINECS号 | |
| 相关类别 | Ion Channels |
| Mol文件 | 5369-03-9.mol |
| 结构式 |  |
QX-314 性质
| 熔点 | 209-211 °C |
|---|---|
| 储存条件 | Room temp |
| 溶解度 | 不溶于乙醇； DMSO 中≥14.95 mg/mL，温和加热；水中≥22.3 mg/mL |
| 形态 | 固体 |
| 颜色 | 白色 |
| 水溶解性 | Soluble in water (100mM) |
| InChI | InChI=1S/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H |
| InChIKey | LLPPOMUAOGMYQI-UHFFFAOYSA-N |
| SMILES | C1(=C(C)C=CC=C1C)NC(=O)C[N+](CC)(CC)CC.[Cl-] |
QX-314 chloride 是一种膜不渗透的钠离子通道永久性电荷阻滞剂。
sodium channel
QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro.
QX-314 chloride (1–60 mM) directly activates TRPV1 in a concentration-dependent manner.
QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca
2+
currents are on average < 45% of control amplitude.
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
|---|---|
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英文
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