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| | 1H-BENZOIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER Basic information |
| Product Name: | 1H-BENZOIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER | | Synonyms: | 1H-BENZIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER;1H-BENZOIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER;BENZIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER;Ethyl 1H-benzimidazole-2-carboxylate;Ethyl 1H-1,3-benzimidazole-2-carboxylate;2-(Ethoxycarbonyl)-1H-benzimidazole;1H-Benzimidazole-2-carboxylicacid,ethylester(9CI);ethyl 1H-1,3-benzodiazole-2-carboxylate | | CAS: | 1865-09-4 | | MF: | C10H10N2O2 | | MW: | 190.2 | | EINECS: | | | Product Categories: | BENZIMIDAZOLE;pharmacetical | | Mol File: | 1865-09-4.mol |  |
| | 1H-BENZOIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER Chemical Properties |
| Melting point | 212.7-213.7 °C | | Boiling point | 350.0±25.0 °C(Predicted) | | density | 1.272±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 10.49±0.10(Predicted) | | form | solid | | color | Beige |
| HazardClass | IRRITANT | | HS Code | 2933998090 |
| | 1H-BENZOIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER Usage And Synthesis |
| Synthesis Reference(s) | The Journal of Organic Chemistry, 39, p. 1519, 1974 DOI: 10.1021/jo00924a014 | | Synthesis | 1H-benzimidazole-2-carboxylic acid (500 mg, 3.08 mmol) was suspended in anhydrous ethanol (5 mL) and thionyl chloride (1.12 mL, 15.4 mmol) was slowly added dropwise, followed by heating the reaction mixture to reflux and stirring overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to afford the crude product ethyl 1H-benzo[d]imidazole-2-carboxylate (644 mg, 99% yield). | | References | [1] Patent: WO2006/91506, 2006, A2. Location in patent: Page/Page column 42
[2] Patent: WO2006/49681, 2006, A2. Location in patent: Page/Page column 40
[3] Patent: WO2006/121588, 2006, A2. Location in patent: Page/Page column 46
[4] Patent: WO2006/121860, 2006, A2. Location in patent: Page/Page column 46
[5] Patent: WO2006/121904, 2006, A1. Location in patent: Page/Page column 46 |
| | 1H-BENZOIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials |
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