(3S)-7-氨基-1-氯-3-磺酰氨基-2-庚酮盐酸盐
| 中文名称 | (3S)-7-氨基-1-氯-3-磺酰氨基-2-庚酮盐酸盐 |
|---|---|
| 中文同义词 | TLCK(进分);NA-对甲苯磺酰-L-赖氨酸氯甲基酮盐酸盐;(3S)-7-氨基-1-氯-3-磺酰氨基-2-庚酮盐酸盐;NΑ-甲苯磺胺基-L-赖氨酸氯甲基酮盐酸盐;(3S)-1-氯-3-甲苯磺酰基氨-7-氨基-2-庚酮盐酸盐;NALPHA-甲苯磺胺基-L-赖氨酸氯甲基酮盐酸盐;NΑ-甲苯磺酰基-L-赖氨酸氯甲基酮盐酸盐;化合物 T16169 |
| 英文名称 | TLCK |
| 英文同义词 | (S)-N-(7-AMino-1-chloro-2-oxoheptan-3-yl)-4-MethylbenzenesulfonaMide hydrochloride;Benzenesulfonamide,N-[(1S)-5-amino-1-(2-chloroacetyl)pentyl]-4-methyl-, hydrochloride (1:1);Tosyl-L-lysyl-chloromethane hydrochloride;Nα-Tosyl-L-lysine chloromethylketone hydrochloride≥ 98% (HPLC);Tos-L-Lys-CMK·HCl;L-1-CHLORO-3-TOSYLAMIDO-7-AMINO-2-HEPTANONE HCL;L-1-CHLORO-3-(4-TOSYLAMIDO)-7-AMINO-2-HEPTANONE HYDROCHLORIDE;(3S)-7-AMINO-1-CHLORO-3-TOSYLAMINO-2-HEPTANONE HYDROCHLORIDE |
| CAS号 | 4272-74-6 |
| 分子式 | C14H21ClN2O3S.ClH |
| 分子量 | 369.31 |
| EINECS号 | 224-266-4 |
| 相关类别 | 细胞裂解蛋白酶抑制剂;氨基酸;氨基酸类;蛋白酶抑制剂;生化试剂-氨基酸类;通用生化试剂-氨基酸;inhibitor |
| Mol文件 | 4272-74-6.mol |
| 结构式 |  |
(3S)-7-氨基-1-氯-3-磺酰氨基-2-庚酮盐酸盐 性质
| 熔点 | ~165 °C (dec.) |
|---|---|
| 储存条件 | -20°C |
| 溶解度 | H2O:50 mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色到粉红色 |
| 旋光度 (Optical Rotation) | [α]20/D 7.8±0.5°, c = 2% in H2O |
| 生物来源 | synthetic (organic) |
| 水溶解性 | H2O: 50mg/mL |
| BRN | 7106867 |
| InChI | 1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1 |
| InChIKey | YFCUZWYIPBUQBD-ZOWNYOTGSA-N |
| SMILES | Cl[H].Cc1ccc(cc1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl |
| CAS 数据库 | 4272-74-6 |
N-alpha-Tosyl-L-lysine chloromethyl ketone exhibits an inhibitory effect on IFN-γ activities. The effect of TLCK is studied on the IFN-γ sensitization of HeLa cells towards cell death mediated by anti-Fas. Lower concentration of anti-Fas (10 ng/mL) are used to examine the interaction among the three effectors simultaneously, that is, anti-Fas, TLCK and IFN-γ. TLCK by itself up to 50 μM concentration exhibits a small decrease in cell viability. Beyond 50 μM, a dose dependent decrease in cell viability is observed. IFN-γ slightly reduces cell viability on its own. Addition of anti-Fas (10 ng/mL) results in a slight decrease in cell survival, which is enhanced more than additively in the presence of TLCK, most prominently between 50 and 100 μM. Upon addition of both anti-Fas and IFN-γ, a decrease (≈46%) in cell viability is observed. Moreover, the decrease in cell survival is further enhanced upon addition of higher concentrations of TLCK, 25 μM and more.
安全信息
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