|
|
| | 1,2,3-BENZOXADIAZOLE-5-CARBALDEHYDE Basic information |
| Product Name: | 1,2,3-BENZOXADIAZOLE-5-CARBALDEHYDE | | Synonyms: | 2,1,3-benzoxadiazole-5-carbaldehyde(SALTDATA: FREE);2,1,3-Benzoxadiazole-5-carboxaldehyde 97%;5-Formyl-2,1,3-benzoxadiazole, 5-Formylbenzofurazan;5-ForMyl-2,1,3-benzoxadiazole;5-ForMylbenzofurazan;Benzo[c][1,2,5]oxadiazole-5-carbaldehyde;2,1,3-Benzoxadiazole-5-carboxaldehyde97%;2,1,3-BENZOXADIAZOLE-5-CARBOXALDEHYDE | | CAS: | 32863-33-5 | | MF: | C7H4N2O2 | | MW: | 148.12 | | EINECS: | 628-471-3 | | Product Categories: | ALDEHYDE | | Mol File: | 32863-33-5.mol |  |
| | 1,2,3-BENZOXADIAZOLE-5-CARBALDEHYDE Chemical Properties |
| Melting point | 58 °C | | Boiling point | 277.3±32.0 °C(Predicted) | | density | 1.417±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -1.68±0.36(Predicted) | | Appearance | White to light yellow Solid | | CAS DataBase Reference | 32863-33-5 |
| Hazard Codes | Xi | | Safety Statements | 24/25 | | HazardClass | IRRITANT | | HS Code | 2934999090 |
| | 1,2,3-BENZOXADIAZOLE-5-CARBALDEHYDE Usage And Synthesis |
| Synthesis | Compound 15 (CAS: 19164-42-2, 10 g, 0.061 mol) was used as starting material and dissolved in dichloromethane (50 mL). A solution of triphenylphosphine (16 g, 0.061 mol) in dichloromethane (50 mL) was slowly added dropwise at 0 °C in an ice bath. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 0 °C for 30 min. Upon completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography using ethyl acetate/petroleum ether (1:20, v/v) as eluent. The target fraction was collected and concentrated to give benzo[c][1,2,5]oxadiazole-5-carbaldehyde (product 16, 6.3 g, 70% yield) as white needle-like crystals. The melting point is 55-56°C (literature values are consistent). | | References | [1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 4, p. 657 - 667 |
| | 1,2,3-BENZOXADIAZOLE-5-CARBALDEHYDE Preparation Products And Raw materials |
|