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Merck KGaA |
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21-20338288 |
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ordercn@merckgroup.com |
| Company Name: |
SIGMA-RBI |
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800 736 3690 (Orders) |
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| | Anti-CenH3, Anti-Centromere Protein A Basic information |
| Product Name: | Anti-CenH3, Anti-Centromere Protein A | | Synonyms: | Anti-CENP-A antibody produced in rabbit;Anti-CENP-A (C-terminal) antibody produced in rabbit;Anti-CenH3, Anti-Centromere Protein A | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Anti-CenH3, Anti-Centromere Protein A Structure]() |
| | Anti-CenH3, Anti-Centromere Protein A Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous solution | | biological source | rabbit |
| WGK Germany | WGK 3 | | Storage Class | 10 - Combustible liquids |
| | Anti-CenH3, Anti-Centromere Protein A Usage And Synthesis |
| Uses | Anti-CENP-A (C-terminal) antibody produced in rabbit is suitable for western blotting at a concentration of 1-2μg/mL using HEK-293 cells expressing human CENP-A. | | General Description | Centromere protein A is a protein encoded by the CENPA gene in humans. It is a histone H3 variant that has centromere-specific nucleosomal property and is located at neocentromere found on chromosome 10. CENP-A- binding clusters is associated with nucleosomal blocks within the neocentromeric chromatin. | | Biochem/physiol Actions | The location of the centromere on the chromosome is dependent on the histone H3 variant centromere protein A (CENP-A). The N-terminal tail of CENP-A is highly different from other H3 variants. Serine 7 of CENP-A plays an important role in mitosis-specific phosphorylation. It also plays a key role in kinetochore assembly. Alteration in CENP-A causes various human cancers. CENP-A may play an important role in epithelial ovarian cancer (EOC) and may serve as prognostic marker. It acts as a potential target for gene therapy in the treatment of EOC. The NH2 terminus of human CENP-A is essential for mitotic progression and necessary for the platform function of CENP-A centromeric chromatin in the assembly as well as maintenance of active kinetochores. |
| | Anti-CenH3, Anti-Centromere Protein A Preparation Products And Raw materials |
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