- Mogrol
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- $0.00 / 20mg
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2023-02-24
- CAS:88930-15-8
- Min. Order: 20mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
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| | (10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol Basic information | | Appearance |
| Product Name: | (10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol | | Synonyms: | (10α,24R)-3β,11α,24,25-Tetrahydroxy-9β-methyl-19-norlanosta-5-ene;(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol;(24R)-Cucurbit-5-ene-3β,11α,24,25-tetrol;Mogrol;Mogrol, >98%;ERK,inhibit,Extracellular signal regulated kinases,STAT,Mogrol,Inhibitor;Monascus alcohol;Mogrol-RM | | CAS: | 88930-15-8 | | MF: | C30H52O4 | | MW: | 476.73 | | EINECS: | | | Product Categories: | | | Mol File: | 88930-15-8.mol |  |
| | (10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol Chemical Properties |
| Boiling point | 595.6±50.0 °C(Predicted) | | density | 1.10±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 14.67±0.29(Predicted) | | color | White to off-white | | CAS DataBase Reference | 88930-15-8 |
| | (10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol Usage And Synthesis |
| Appearance | Constit. of Cucurbita foeridissimia (buffalo gourd).Amorph. powder. | | Uses | Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling. | | Definition | ChEBI: Mogrol is a tetracyclic triterpenoid that is cucurbitadienol in which the side-chain double bond (position 24-25) has undergone formal oxidation to introduce hydroxy groups at positions 24 and 25 (the 24R stereoisomer). It is a biometabolite of mogrosides found in Siraitia grosvenorii. It has a role as an antineoplastic agent. It is a tetracyclic triterpenoid and a hydroxy seco-steroid. It is functionally related to a cucurbitadienol. | | Biochem/physiol Actions | Mogrol is an aglycone of mogrosides from Siraitia grosvenorii that exhibits neuroprotective and anticancer activities. It induces apoptosis in K562 leukemia cells through suppression of ERK1/2 and STAT3 pathways. Mogrol appears to ameliorate the memory impairment caused by Aβ1-42 in mice. Mogrol increases AMPK activity in hepatocytes and suppresses adipocyte differentiation in 3T3-L1 cells. | | IC 50 | ERK1; ERK2; STAT3 | | References | [1] Liu C, et al. Mogrol represents a novel leukemia therapeutic, via ERK and STAT3 inhibition. Am J Cancer Res. 2015 Mar 15;5(4):1308-18.
[2] Naoki Harada, et al. Mogrol Derived from Siraitia grosvenorii Mogrosides Suppresses 3T3-L1 Adipocyte Differentiation by Reducing cAMP-Response Element-Binding Protein Phosphorylation and Increasing AMP-Activated Protein Kinase Phosphorylation. PLoS One. 2 |
| | (10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol Preparation Products And Raw materials |
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