罗卡斯汀
| 中文名称 | 罗卡斯汀 |
|---|---|
| 中文同义词 | 罗卡斯汀;化合物 T16778;化合物 Rocastine |
| 英文名称 | 2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione |
| 英文同义词 | 2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f][1,4]oxazepine-5(2H)-thione;2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione;Pyrido[3,2-f]-1,4-oxazepine-5(2H)-thione, 2-[2-(dimethylamino)ethyl]-3,4-dihydro-4-methyl- |
| CAS号 | 91833-49-7 |
| 分子式 | C13H19N3OS |
| 分子量 | 265.37 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 91833-49-7.mol |
| 结构式 |  |
罗卡斯汀 性质
| 熔点 | 130-133 °C |
|---|---|
| 沸点 | 379.0±52.0 °C(Predicted) |
| 密度 | 1.20±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 9.18±0.28(Predicted) |
Rocastine 是一种选择性的，非镇静的 H1 拮抗剂，为抗组胺剂。
Rocastine is effective with a 15 min pretreatment time (PD 50 = 0.13 mg/kg) as it is with a 1 hr pretreatment time (PD 50 = 0.12 mg/kg). Rocastine protects guinea pigs from collapse induced by aerosolized antigen; rocastine is approximately 36x more potent than diphenhydramine and as potent as oxatomide and terfenadine. Rocastine does not alter the EEG of cats at doses in vast excess (150x) of its antihistaminic dose nor does it potentiate yohimbine toxicity in mice.