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Spirolaxin manufacturers
- Spirolaxine
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- $1720.00
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2026-05-11
- CAS:126382-01-2
- Purity:
- Supply Ability: 10g
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| | Spirolaxin Basic information |
| Product Name: | Spirolaxin | | Synonyms: | (3R)-5-Hydroxy-7-methoxy-3-[5-[(2R,5R,7R)-2-methyl-1,6-dioxaspiro[4.5]decane-7-yl]pentyl]isobenzofuran-1(3H)-one;Spirolaxin;Spirolaxine;1(3H)-Isobenzofuranone, 5-hydroxy-7-methoxy-3-[5-[(2R,5R,7R)-2-methyl-1,6-dioxaspiro[4.5]dec-7-yl]pentyl]-, (3R)- | | CAS: | 126382-01-2 | | MF: | C23H32O6 | | MW: | 404.5 | | EINECS: | | | Product Categories: | | | Mol File: | 126382-01-2.mol |  |
| | Spirolaxin Chemical Properties |
| Boiling point | 600.884±55.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.222±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | A solid | | pka | 7.698±0.40(predicted) |
| | Spirolaxin Usage And Synthesis |
| Description | Spirolaxine is a long-chain phthalide produced by the fungus S. laxum that has antibacterial properties. Spirolaxine is a potent anti-H. pylori agent (MIC = 0.2 μg/cm3) with weak activity against E. coli. Spirolaxine (1-40 μM) inhibits proliferation of endothelial (BMEC, HUVEC) and tumor (LoVo, HL-60) cells in culture. B. megaterium and C. echinulate produce hydroxylated metabolites of spirolaxine when given spirolaxine as a substrate. | | Uses | Spirolaxine is a bioactive undecaketide fungal metabolite found in Sporotrichum laxum ATCC 15155. Spirolaxine exhibits anti-Helicobacter pylori property. | | IC 50 | Microbial Metabolite | | References | [1] ALBERTO ARNONE . Spirolaxine and sporotricale: Two long-chain phthalides produced by Sporotrichum laxum[J]. Phytochemistry, 1990, 29 2: Pages 613-616. DOI: 10.1016/0031-9422(90)85127-2
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[3] A. LEóN. Phthalides: Distribution in Nature, Chemical Reactivity, Synthesis, and Biological Activity.[J]. Progress in the chemistry of organic natural products, 2017, 26 1: 127-246. DOI: 10.1007/978-3-319-45618-8_2
[4] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[5] GIANLUCA NASINI. Microbial Transformation of Spirolaxine, a Bioactive Undecaketide Fungal Metabolite from the Basidiomycete Sporotrichum laxum[J]. Chemistry & Biodiversity, 2007, 4 12: 2772-2779. DOI: 10.1002/cbdv.200790226 |
| | Spirolaxin Preparation Products And Raw materials |
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