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| | (Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole hydrochloride Basic information |
| | (Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole hydrochloride Chemical Properties |
| solubility | Soluble to 5 mM in DMSO with gentle warming and to 5 mM in ethanol with gentle warming |
| | (Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole hydrochloride Usage And Synthesis |
| Uses | Loreclezole Hydrochloride is the hydrochoride salt of Loreclezole, which provides γ-aminobutyric acid type A receptors modulation. | | in vivo | Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the "pull-up" test[3]. | Animal Model: | Adult male Lister Hooded rats[3]. | | Dosage: | 10, 25, 50 or 75 mg/kg. | | Administration: | IP, 60 min before measurement of seizure threshold. | | Result: | Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. |
| | storage | Desiccate at -20°C |
| | (Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole hydrochloride Preparation Products And Raw materials |
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