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| | 2-(4-Aminophenyl)quinoline Basic information |
| Product Name: | 2-(4-Aminophenyl)quinoline | | Synonyms: | 2-(4-Aminophenyl)quinoline;(4-Quinolin-2-ylphenyl)amine;[4-(2-quinolyl)phenyl]amine;4-(2-quinolyl)aniline;4-quinolin-2-ylaniline;Benzenamine, 4-(2-quinolinyl)-;BF-170 hydrochloride >=98% (HPLC), solid;4-(2-Quinolinyl)benzenamine | | CAS: | 22191-97-5 | | MF: | C15H12N2 | | MW: | 220.27 | | EINECS: | | | Product Categories: | | | Mol File: | 22191-97-5.mol |  |
| | 2-(4-Aminophenyl)quinoline Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: soluble10mg/mL | | form | solid | | color | orange | | Water Solubility | H2O: 10mg/mL | | InChI | 1S/C15H12N2.ClH/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15;/h1-10H,16H2;1H | | InChIKey | UYYPMQOFLJHJAW-UHFFFAOYSA-N | | SMILES | Cl[H].Nc1ccc(cc1)-c2ccc3ccccc3n2 |
| Hazard Codes | Xn | | Risk Statements | 22-37/38-41 | | Safety Statements | 26 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 2-(4-Aminophenyl)quinoline Usage And Synthesis |
| Uses | BF-170 is a selective tau fibril binding agent with an EC50 of 221 nM. It exhibits good blood-brain barrier permeability, and after intravenous injection in mice, the concentration in brain tissue reaches 9.1% ID/g within 2 minutes (with a brain clearance rate of 0.25% ID/g after 30 minutes). BF-170 can be used as a probe for tau protein pathology imaging in Alzheimer's disease (AD). It plays an important role in early-stage AD research and holds potential for imaging studies of tau-related neurodegenerative diseases[1]. | | Biological Activity | BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC50 = 221 nM vs. EC50 = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimerμs disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD. | | References | [1] Okamura N, et al. Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease. J Neurosci. 2005 Nov 23;25(47):10857-62. DOI:10.1523/JNEUROSCI.1738-05.2005 |
| | 2-(4-Aminophenyl)quinoline Preparation Products And Raw materials |
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