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| | MONOCLONAL ANTI-HNRNP-A1 Basic information |
| Product Name: | MONOCLONAL ANTI-HNRNP-A1 | | Synonyms: | Monoclonal Anti-hnRNP-A1 antibody produced in mouse;Anti-HNRPA1 (AB2) antibody produced in rabbit;Anti-hnRNP A1 (Ab-192) antibody produced in rabbit;Anti-HNRPA1 (AB1) antibody produced in rabbit;Anti-HNRNPA1 antibody produced in rabbit;MONOCLONAL ANTI-HNRNP-A1;Anti-heterogeneous nuclear ribonucleoprotein-A1;Anti-hnRNP-A1 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![MONOCLONAL ANTI-HNRNP-A1 Structure]() |
| | MONOCLONAL ANTI-HNRNP-A1 Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous solution | | biological source | rabbit |
| WGK Germany | 3 | | Storage Class | 10 - Combustible liquids |
| | MONOCLONAL ANTI-HNRNP-A1 Usage And Synthesis |
| Uses | All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit . | | General Description | HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) is a ribonucleoprotein, which functions as an RNA-binding protein. It can interact with both RNA and DNA, through its two nucleic acid-binding domains. It is proteolytically cleaved into a 196-amino acid protein called UP1 (unwinding protein 1). This protein retains the two parent nucleic acid-binding domains. It is one of the major RNA-binding proteins, and though it localizes to nucleus, it can shuttle to cytoplasm as well. | | Biochem/physiol Actions | HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) functions in mRNA metabolism. It shuttles continuously between nucleus and cytoplasm and functions in several processes such as mRNA export, internal ribosome entry site (IRES)-mediated translation and mRNA stability. In humans, it acts as an auxiliary factor for the processing of a specific miRNA substrate by binding specifically to pri-miR-18a, the stem-loop precursor of miR-18a and regulating its Drosha-mediated processing. Defects in this gene are associated with multisystem proteinopathy and ALS (Amyotrophic lateral sclerosis 20). An alternatively spliced isoform of this protein is capable of controlling the splicing and replication of human immunodeficiency virus (HIV)-1. |
| | MONOCLONAL ANTI-HNRNP-A1 Preparation Products And Raw materials |
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