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| | TRECOVIRSEN Basic information |
| Product Name: | TRECOVIRSEN | | Synonyms: | D(p-Thio)(C-T-C-T-C-G-C-A-C-C-C-A-T-C-T-C-T-C-T-C-C-T-T-C-T)-dna;Deoxyribonucleic acid, D(p-thio)(C-T-C-T-C-G-C-A-C-C-C-A-T-C-T-C-T-C-T-C-C-T-T-C-T)-;Dna, D(p-thio)(C-T-C-T-C-G-C-A-C-C-C-A-T-C-T-C-T-C-T-C-C-T-T-C-T)- | | CAS: | 153021-75-1 | | MF: | C237H310N72O131P24S24 | | MW: | 7776.331364 | | EINECS: | | | Product Categories: | | | Mol File: | 153021-75-1.mol |  |
| | TRECOVIRSEN Chemical Properties |
| form | Solid | | color | White to off-white |
| | TRECOVIRSEN Usage And Synthesis |
| Uses | Trecovirsen (GEM91) is a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene. | | References | [1] Séréni D, Tubiana R, Lascoux C, et al. Pharmacokinetics and tolerability of intravenous trecovirsen (GEM 91), an antisense phosphorothioate oligonucleotide, in HIV-positive subjects. J Clin Pharmacol. 1999;39(1):47-54. DOI:10.1177/00912709922007552
[2] Pedziwiatr-Werbicka E, Fuentes E, Dzmitruk V, et al. Novel 'Si-C' carbosilane dendrimers as carriers for anti-HIV nucleic acids: studies on complexation and interaction with blood cells. Colloids Surf B Biointerfaces. 2013;109:183-189. DOI:10.1016/j.colsurfb.2013.03.045 |
| | TRECOVIRSEN Preparation Products And Raw materials |
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