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| | SINOVA SL-03967 Basic information |
| Product Name: | SINOVA SL-03967 | | Synonyms: | Cyclopropanecarboxylic acid, 1-[[(1,1-diMethylethoxy)carbonyl]aMino]-, ethyl ester;1-N-(BOC)AMino-cyclopropane-1-carboxylic acid ethyl ester;1-[[(1,1-dimethylethoxy)carbonyl]amino]Cyclopropane carboxylic acid Ethyl ester;SINOVA SL-03967;Ethyl 1-(Boc-aMino)cyclopropanecarboxylate;Ethyl 1-[(2-methylpropan-2-yl)oxycarbonylamino]cyclopropane-1-carboxylate;Ethyl1-((tert-butoxycarbonyl)amino)cyclopropanecarboxylate
CAS：107259-05-2;Ethyl 1-((tert-butoxycarbonyl)aMino)cyclopropanecarboxylate | | CAS: | 107259-05-2 | | MF: | C11H19NO4 | | MW: | 229.27 | | EINECS: | | | Product Categories: | | | Mol File: | 107259-05-2.mol |  |
| | SINOVA SL-03967 Chemical Properties |
| Melting point | 44-46 °C(Solv: pentane (109-66-0)) | | Boiling point | 307.0±21.0 °C(Predicted) | | density | 1.10±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 10.87±0.20(Predicted) | | Appearance | White to off-white Solid |
| | SINOVA SL-03967 Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of ethyl 1-(BOC-amino)cyclopropane-1-carboxylate from di-tert-butyl dicarbonate and ethyl 1-aminocyclopropane-1-carboxylate hydrochloride was as follows: to a solution of 1-aminocyclopropane carboxylic acid ethyl ester hydrochloride (3.22 g, 19.4 mmol) in dichloromethane (35 mL) was added triethylamine (2.71 mL, 19.4 mmol) to form a suspension. A solution of dichloromethane (5 mL) of di-tert-butyl dicarbonate (4.24 g, 19.4 mmol) was added slowly and dropwise over about 5 hours. The reaction mixture was stirred overnight at room temperature. After completion of the reaction, extraction was carried out by adding 1 M aqueous KHSO4 solution (100 mL) and dichloromethane (50 mL). The organic layer was separated, dried over anhydrous sodium sulfate, the solvent was evaporated under reduced pressure and co-evaporated with tetrahydrofuran (2×) to give 4.31 g (97% yield) of ethyl 1-(BOC-amino)cyclopropanecarboxylate. | | References | [1] Patent: WO2015/90603, 2015, A1. Location in patent: Page/Page column 59; 60
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 7, p. 2151 - 2155 |
| | SINOVA SL-03967 Preparation Products And Raw materials |
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