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| | 1H-PYRAZOLO[3,4-C]PYRIDIN-3-AMINE Basic information |
| Product Name: | 1H-PYRAZOLO[3,4-C]PYRIDIN-3-AMINE | | Synonyms: | 1H-PYRAZOLO[3,4-C]PYRIDIN-3-AMINE;4-c]pyridin-3-aMine;1H-Pyrazolo[3,4-c]pyridin-3-amine, 3-Amino-6-azaindole;3-Amino-1H-pyrazolo[3,4-c]pyridine;3-Amino-6-aza-1H-indazole;1H-Pyrazolo[3,4-c]pyridin-3-ylamine;3-Amino-1H-pyrazolo[3,4-c]pyridine 95+%;2H-pyrazolo[3,4-c]pyridin-3-amine | | CAS: | 76006-17-2 | | MF: | C6H6N4 | | MW: | 134.14 | | EINECS: | | | Product Categories: | | | Mol File: | 76006-17-2.mol | ![1H-PYRAZOLO[3,4-C]PYRIDIN-3-AMINE Structure](CAS/GIF/76006-17-2.gif) |
| | 1H-PYRAZOLO[3,4-C]PYRIDIN-3-AMINE Chemical Properties |
| Melting point | 213-214 °C(Solv: ethanol (64-17-5)) | | Boiling point | 433.5±25.0 °C(Predicted) | | density | 1.480±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | form | solid | | pka | 11.83±0.40(Predicted) | | Appearance | White to yellow Solid | | InChI | 1S/C6H6N4/c7-6-4-1-2-8-3-5(4)9-10-6/h1-3H,(H3,7,9,10) | | InChIKey | LGZRIKTZAOPKET-UHFFFAOYSA-N | | SMILES | Nc1n[nH]c2cnccc12 |
| Hazard Codes | T | | Risk Statements | 25-36 | | Safety Statements | 26-45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | WGK 3 | | HS Code | 2933399990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Irrit. 2 |
| | 1H-PYRAZOLO[3,4-C]PYRIDIN-3-AMINE Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 1H-pyrazolo[3,4-c]pyridin-3-amine using 3-fluoro-4-cyanopyridine as starting material: 3-fluoro-4-cyanopyridine (0.50 g, 4.10 mmol) was dissolved in ethanol (8 mL), followed by addition of hydrazine hydrate (0.31 g, 6.1 mmol). The reaction mixture was stirred at 70 °C for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated and dried under vacuum to afford the target product 1H-pyrazolo[3,4-c]pyridin-3-amine (0.66 g, 100% yield). The product was characterized by LC-MS (Method 2B): retention time (Rt) = 0.51 min, mass spectrum (ESI positive ion mode): m/z = 135 [M + H]+. | | References | [1] Patent: WO2015/67549, 2015, A1. Location in patent: Page/Page column 66
[2] Patent: US2015/126449, 2015, A1. Location in patent: Paragraph 0386 - 0388 |
| | 1H-PYRAZOLO[3,4-C]PYRIDIN-3-AMINE Preparation Products And Raw materials |
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