| Company Name: |
Shanghai Devinchem Ltd
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| Tel: |
027-65318838 13646286950 |
| Email: |
sales@devinchem.com |
| Products Intro: |
Product Name:3-Nitro-6-azaindole
CAS:67058-77-9
Purity:97% Package:5g Remarks:CL0374
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| Company Name: |
Henan Weituxi Chemical Technology Co., Ltd.
|
| Tel: |
0371-63284658 18135795563 |
| Email: |
3905209149@qq.com |
| Products Intro: |
Product Name:3-NITRO-6-AZAINDOLE
CAS:67058-77-9
Purity:98% Package:100mg；500mg；1g;5g;25g
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3-NITRO-6-AZAINDOLE manufacturers
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| | 3-NITRO-6-AZAINDOLE Basic information |
| | 3-NITRO-6-AZAINDOLE Chemical Properties |
| storage temp. | 2-8°C | | Appearance | Off-white to light yellow Solid |
| | 3-NITRO-6-AZAINDOLE Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 3-nitro-1H-pyrrolo[2,3-c]pyridine from 6-azaindole: 69% nitric acid (533 mg, 8.47 mmol) was slowly added to a solution of 1H-pyrrolo[2,3-c]pyridine (1 g, 8.47 mmol) in concentrated sulfuric acid (5 mL) at 0 °C. The reaction mixture was stirred at 0 °C for 2 h before gradually warming to room temperature and continuing to stir overnight. Upon completion of the reaction, the mixture was carefully poured into water (100 mL) and the pH was adjusted with sodium hydroxide powder to >7. Subsequently, the mixture was extracted with ethyl acetate (100 mL x 3), the organic phases were combined and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to afford 3-nitro-1H-pyrrolo[2,3-c]pyridine (690 mg, 50% yield) as a yellow solid. The product was confirmed by NMR hydrogen spectroscopy (400 MHz, DMSO-d6): δ=8.94 (s, 1H), 8.85 (s, 1H), 8.44 (d, J=5.2 Hz, 1H), 8.02 (dd, J=5.6,1.2 Hz, 1H). Mass spectral analysis showed m/z of 164.0 (M+H). | | References | [1] Patent: WO2018/132372, 2018, A1. Location in patent: Paragraph 00729 |
| | 3-NITRO-6-AZAINDOLE Preparation Products And Raw materials |
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