| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
|
| Tel: |
18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:UBP 310;(S)-1-(2-AMino-2-carboxyethyl)-3-(2-carboxy-thiophene-3-yl-Methyl)-5-MethylpyriMidine-2,4-dione
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
|
| Company Name: |
Ascent Scientific
|
| Tel: |
4401179829988 |
| Email: |
customerservice@ascentscientific.co.uk |
| Products Intro: |
Product Name:UBP310
Purity:>98% Package:10mg;50mg Remarks:GluK1 and GluK3 selective antagonist
|
|
| Product Name: | UBP310 | | Synonyms: | UBP310;(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione;receptor,glutamate,inhibit,UBP310,Ionotropic glutamate receptors,GluR5,Inhibitor,UBP-310,iGluR;1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(2-carboxy-3-thienyl)methyl]-3,4-dihydro-5-methyl-2,4-dioxo-, (αS)-;UBP310, GluK1 and GluK3 selective antagonist | | CAS: | 902464-46-4 | | MF: | C14H15N3O6S | | MW: | 353.35 | | EINECS: | | | Product Categories: | Glutamate | | Mol File: | 902464-46-4.mol |  |
| | UBP310 Chemical Properties |
| Melting point | 226-228 °C (decomp)(Solv: water (7732-18-5)) | | Boiling point | 615.2±65.0 °C(Predicted) | | density | 1.564±0.06 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | DMSO: Slightly Soluble | | form | A crystalline solid | | pka | 2.12±0.10(Predicted) | | color | White to off-white | | InChI | 1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1 | | InChIKey | ZTAZUCRXCRXNSU-VIFPVBQESA-N |
| WGK Germany | WGK 2 | | Storage Class | 11 - Combustible Solids |
| | UBP310 Usage And Synthesis |
| Description | UBP 310 is an antagonist of ionotropic glutamate receptor 5 (GluR5 or GluK1; Kd = 130 nM). It less potently binds GluR2 (GluA2) and GluR6 (GluK2; Kds = 106 and 1,626 μM, respectively). UBP 310 is inactive at metabotropic GluR group I and NMDA receptors. | | Uses | UBP 310 is a GLUK5 kainate receptor antagonist. | | storage | Store at +4°C | | References | [1] PALMI T ATLASON. Mapping the ligand binding sites of kainate receptors: molecular determinants of subunit-selective binding of the antagonist [3H]UBP310.[J]. ACS Applied Electronic Materials, 2010: 1036-1045. DOI: 10.1124/mol.110.067934
[2] MARK L MAYER. Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.[J]. ACS Applied Energy Materials, 2006: 2852-2861. DOI: 10.1523/jneurosci.0123-06.2005
[3] DAVID PERRAIS . Antagonism of recombinant and native GluK3-containing kainate receptors[J]. Neuropharmacology, 2009, 56 1: Pages 131-140. DOI: 10.1016/j.neuropharm.2008.08.002
[4] MEI DU V J Anu Rambhadran. Luminescence resonance energy transfer investigation of conformational changes in the ligand binding domain of a kainate receptor.[J]. The Journal of Biological Chemistry, 2008, 283 40: 27074-27078. DOI: 10.1074/jbc.m805040200 |
| | UBP310 Preparation Products And Raw materials |
|