| Company Name: |
skychemical Co.Ltd
|
| Tel: |
021-20958197 20965099 |
| Email: |
sales@skychemical.com |
| Products Intro: |
Product Name:5-IODO-THIOPHENE-2-CARBOXYLIC ACID
CAS:60166-85-0
Purity:98%
|
|
| | 5-Iodo-thiophene-2-carboxylic acid Basic information |
| | 5-Iodo-thiophene-2-carboxylic acid Chemical Properties |
| Melting point | 133 °C | | Boiling point | 344.0±27.0 °C(Predicted) | | density | 2.238±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 3.28±0.10(Predicted) | | Appearance | White to light yellow Solid |
| | 5-Iodo-thiophene-2-carboxylic acid Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 5-iodothiophene-2-carboxylic acid (P-2) from methyl 5-iodothiophene-2-carboxylate (P-1): to a 17.5 mL aqueous solution of lithium hydroxide (0.45 g, 11.19 mmol) was added a 35 mL tetrahydrofuran solution of compound P-1 (1.0 g, 3.73 mmol). The reaction mixture was stirred at room temperature for 4 h. The pH was subsequently adjusted to 4 with acid and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 0.86 g (91% yield) of the target compound P-2 as a white solid.1H NMR (400 MHz, CD3OD) δ 7.35 (d, J = 3.8 Hz, 1H), 7.43 (d, J = 3.9 Hz, 1H). | | References | [1] Patent: US6274620, 2001, B1 |
| | 5-Iodo-thiophene-2-carboxylic acid Preparation Products And Raw materials |
|