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| | 2-(4-Amino-1H-pyrazol-1-yl)ethanol Basic information |
| Product Name: | 2-(4-Amino-1H-pyrazol-1-yl)ethanol | | Synonyms: | 2-(4-Amino-1H-pyrazol-1-yl)ethanol;2-(4-Amino-1H-pyrazol-1-yl)ethanol (Related Reference);2-(3-Amino-1H-pyrazol-1-yl);2-(3-AMINOPYRAZOL-1-YL)ETHANOL;1H-Pyrazole-1-ethanol, 3-aMino-;2-(3-amino-1H-pyrazol-1-yl)ethan-1-ol;2-(3-Amino-1-pyrazolyl)ethanol;2-(3-AMino-1H-pyrazol-1-yl)ethanol | | CAS: | 84407-13-6 | | MF: | C5H9N3O | | MW: | 127.14 | | EINECS: | | | Product Categories: | | | Mol File: | 84407-13-6.mol |  |
| | 2-(4-Amino-1H-pyrazol-1-yl)ethanol Chemical Properties |
| Boiling point | 337.9±22.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 14.42±0.10(Predicted) | | Appearance | Colorless to off-white Solid |
| | 2-(4-Amino-1H-pyrazol-1-yl)ethanol Usage And Synthesis |
| Uses | 2-(3-Amino-1H-pyrazol-1-yl)ethanol is a reagent in the preparation of pyrazolo pyrimidines with CK2 kinase inhibitory activity. | | Synthesis | General procedure for the synthesis of 2-(4-amino-1H-pyrazol-1-yl)ethanol from 3-nitro-1H-pyrazol-1-ethanol: 2-(3-nitro-1H-pyrazol-1-yl)ethanol (0.187 g, 1.19 mmol) was dissolved in ethanol (6 mL) and 10% palladium/carbon catalyst (20 mg) was added under argon protection. The reaction mixture was stirred overnight at room temperature and under hydrogen atmosphere (using a hydrogen balloon). Upon completion of the reaction, the insoluble material was removed by filtration through a diatomaceous earth pad and washed with ethanol. The filtrate and washings were combined and concentrated under reduced pressure to remove the solvent to give the target product 2-(4-amino-1H-pyrazol-1-yl)ethanol (light brown tar-like substance, 0.151 g, 1.18 mmol, 99% yield). | | References | [1] Patent: JP5829520, 2015, B2. Location in patent: Paragraph 0469
[2] Patent: WO2016/180843, 2016, A1. Location in patent: Page/Page column 43
[3] Patent: WO2008/156757, 2008, A1. Location in patent: Page/Page column 234
[4] Patent: US2012/283271, 2012, A1. Location in patent: Page/Page column 11
[5] Patent: WO2013/17479, 2013, A1. Location in patent: Page/Page column 43-44 |
| | 2-(4-Amino-1H-pyrazol-1-yl)ethanol Preparation Products And Raw materials |
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