| Company Name: |
ApexBio Technology LLC
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| Tel: |
+1-832-696-8203 |
| Email: |
info@apexbt.com |
| Products Intro: |
Product Name:ScraMbled 10Panx
CAS:1315378-72-3
Package:1Mg
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| Company Name: |
Creative Peptides
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| Tel: |
|
| Email: |
info@creative-peptides.com |
| Products Intro: |
Product Name:Scrambled10Panx
CAS:1315378-72-3
Purity:>98% Package:1g; 10g;100g;1kg Remarks:Peptide Inhibitors
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| Company Name: |
Chengdu Youngshe Chemical Co., Ltd.
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| Tel: |
+86-17380623303 +86-17380623303 |
| Email: |
Caroline@youngshechem.com |
| Products Intro: |
Product Name:Scrambled 10Panx
CAS:1315378-72-3
Purity:95% Package:1G; 10G; 100G
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| | Scrambled 10Panx Basic information |
| Product Name: | Scrambled 10Panx | | Synonyms: | Scrambled 10Panx;SCPANX;L-Arginine, L-phenylalanyl-L-seryl-L-valyl-L-tyrosyl-L-tryptophyl-L-alanyl-L-glutaminyl-L-alanyl-L-α-aspartyl-;Scrambled 10Panx1 trifluoroacetate salt;Scrambled 10Panx trifluoroacetate | | CAS: | 1315378-72-3 | | MF: | C58H79N15O16 | | MW: | 1242.36 | | EINECS: | | | Product Categories: | peptides | | Mol File: | 1315378-72-3.mol |  |
| | Scrambled 10Panx Chemical Properties |
| density | 1.48±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≥31.05 mg/mL in DMSO | | form | solid | | pka | 3.17±0.10(Predicted) | | color | white to off-white | | Water Solubility | Soluble to 0.50 mg/ml in water |
| | Scrambled 10Panx Usage And Synthesis |
| Uses | Scrambled 10Panx (FSVYWAQADR) is a random sequence variant of a specific inhibitory peptide 10Panx targeted at the half-channel of Pannexin-1 (Panx1). Scrambled 10Panx is used as a control peptide to determine whether other experimental conditions or peptides act through specific molecular mechanisms. Scrambled 10Panx can be used for research in neurobiology and cell biology[1]. | | Biological Activity | scrambled 10panx is the scrambled form of 10panx (wrqaafvdsy), a mimetic peptide of pannexin 1 that inhibits dye uptake by macrophages without affecting cellular membrane currents. being structurally similar to anther peptide panxe1b, 10panx is three amino acid shorter but exerting an inhibitory effect against pannexin1 currents in oocytes to a similar extent as panxe1b. 10panx is also able to block the activation of i2nd, decrease the bradykinin-induced [ca2+]i response and attenuate bradykinin-induced atp release from human fibroblasts loaded with quinacrine. however, in several studies, scrambled 10panx has been proved to be less effective than 10panx in its authentic form.roger j. thompson, michael f. jackson, michelle e. olah, ravi l. rungta, dustin j. hines, michael a. beazely, john f. macdonald, brian a. macvicar. activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. science 2008; 322: 1555-1559.ana rita pinheiro, diogo paramos-de-carvalho, marianna certal, cristina costa, maria teresa magalhaes-cardoso, fatima ferreirinha, maria adelina costa and paulo correia-de-sa. bradykinin-induced ca2+ signaling in human subcutaneous fibroblasts involves atp release via hemichannels leading to p2y12 receptors activation. communication and signaling 2013, 11:70junjie wang, meiyun ma, silviu locovei, robert w. keane and gerhard dahl. modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. am j physiol cell physiol 293: c1112-c1119, 2007 | | References | [1] Thompson R J, et al. Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus[J]. Science, 2008, 322(5907): 1555-1559. DOI:10.1126/science.1165209 |
| | Scrambled 10Panx Preparation Products And Raw materials |
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