3,5-DibroMo-1-Methylpyrazin-2(1H)-one manufacturers
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| | 3,5-DibroMo-1-Methylpyrazin-2(1H)-one Basic information | | Uses |
| Product Name: | 3,5-DibroMo-1-Methylpyrazin-2(1H)-one | | Synonyms: | 3,5-DibroMo-1-Methylpyrazin-2(1H)-one;3,5-dibroMo-1-Methyl-1,2-dihydropyrazin-2-one;2(1H)-Pyrazinone, 3,5-dibroMo-1-Methyl-;3,5-Dibromo-1-methylpyrazin-2(1H);3,5-Dibromo-1-methylpyrazin-2-one;2-methyl-1,3-thiazole-23-carboxylic acid | | CAS: | 87486-34-8 | | MF: | C5H4Br2N2O | | MW: | 267.91 | | EINECS: | | | Product Categories: | | | Mol File: | 87486-34-8.mol |  |
| | 3,5-DibroMo-1-Methylpyrazin-2(1H)-one Chemical Properties |
| Melting point | 98 °C | | Boiling point | 261.9±50.0 °C(Predicted) | | density | 2.20±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -6.54±0.70(Predicted) | | Appearance | White to light brown Solid |
| | 3,5-DibroMo-1-Methylpyrazin-2(1H)-one Usage And Synthesis |
| Uses | 3,5-Dibromo-1-methylpyrazine-2(1H)-one can be used as a pharmaceutical synthesis intermediate, such as in the preparation of 5-bromo-3-(4-(1,4-dimethyl-3-oxopirarin-2-yl)phenylamino)-1-methylpyrazine-2(1H)-one, which can be prepared by reacting 1,2-dichlorobenzene with oxalyl bromide. | | Synthesis | To a suspension of 2-methylaminoacetonitrile hydrochloride (20 g, 142.0 mmol) in dichloromethane (DCM, 1300 mL) was slowly added oxalyl bromide (54 mL, 188.67 mmol), followed by the dropwise addition of N,N-dimethylformamide (DMF, 1.5 mL) at 0 °C. The reaction mixture was warmed to 55 °C and stirred for 16 hours. Upon completion of the reaction, the dichloromethane was removed by distillation under reduced pressure and the crude product obtained was purified by column chromatography using 2% methanol/dichloromethane (MeOH/CH2Cl2) as eluent to afford the target compound 3,5-dibromo-1-methylpyrazin2(1H)-one as a light yellow solid (34 g, 92% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 8.1 (s, 1H), 3.4 (s, 3H).LC-MS analysis showed the molecular ion peak m/z 268.9 ([M + 1]+). | | References | [1] Patent: WO2014/108820, 2014, A1. Location in patent: Page/Page column 27
[2] Patent: WO2014/125410, 2014, A1. Location in patent: Page/Page column 23; 24 |
| | 3,5-DibroMo-1-Methylpyrazin-2(1H)-one Preparation Products And Raw materials |
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