- Nodinitib-1
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- $50.00 / 5mg
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2025-09-22
- CAS:799264-47-4
- Min. Order:
- Purity: 99.97%
- Supply Ability: 10g
- Nodinitib-1
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- $1.00 / 1g
-
2019-12-24
- CAS:799264-47-4
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 20kg
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| | Nodinitib-1 Basic information |
| | Nodinitib-1 Chemical Properties |
| Melting point | 191-192 °C (decomp) | | Boiling point | 532.5±43.0 °C(Predicted) | | density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | DMSO: >10mg/mL | | form | powder | | pka | 2.55±0.10(Predicted) | | color | white to beige |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| | Nodinitib-1 Usage And Synthesis |
| Uses | Noditinib-1 is a potent and selective inhibitor of NOD1-induced NF-κB activation. Mutations in NOD proteins have been associated with various inflammatory diseases and Noditinib-1 shows promise as a potential therapeutic agent. | | Definition | ChEBI: 1-(4-methylphenyl)sulfonyl-2-benzimidazolamine is a sulfonamide. | | Biological Activity | Nodinitib-1 (ML130) is a selectiove inhibitor of of the nucleotide oligomerization domain (NOD)-1 receptor, which is involved in innate immune response and has been associated with several inflammatory diseases. NOD1 and NOD2 recognize distinct structures derived from bacterial peptidoglycans and directly activate NF-?B pathway, which controls the production of proinflammatory molecules. Nodinitib-1 has 40:1 selectivity for NOD1 over NOD2. | | IC 50 | NOD1 |
| | Nodinitib-1 Preparation Products And Raw materials |
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