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| | PAD1 (human recombinant) Basic information |
| | PAD1 (human recombinant) Chemical Properties |
| | PAD1 (human recombinant) Usage And Synthesis |
| Description | Protein Arginine Deiminases (PADs) are guanidino-modifying enzymes belonging to the amidinotransferase superfamily and are designated PAD1-4 and PAD6. PADs are calcium-dependent enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline. The various PADs exhibit tissue specific expression and different subcellular localization. PAD1 is expressed in uterus and throughout the epidermis. PAD1 and PAD3 are speculated to mediate deimination of epidermal filaggrin (filament aggregation protein) and keratins, proteins involved in maintaining skin hydration. | | References | [1] JOYCE J.B.C. VAN BEERS. Peptidylarginine deiminase expression and activity in PAD2 knock-out and PAD4-low mice[J]. Biochimie, 2013, 95 2: Pages 299-308. DOI: 10.1016/j.biochi.2012.09.029
[2] SHINYA SAIJO . Monomeric Form of Peptidylarginine Deiminase Type I Revealed by X-ray Crystallography and Small-Angle X-ray Scattering[J]. Journal of Molecular Biology, 2016, 428 15: Pages 3058-3073. DOI: 10.1016/j.jmb.2016.06.018
[3] RACHIDA NACHAT . Peptidylarginine Deiminase Isoforms 1–3 Are Expressed in the Epidermis and Involved in the Deimination of K1 and Filaggrin[J]. Journal of Investigative Dermatology, 2005, 124 2: Pages 384-393. DOI: 10.1111/j.0022-202x.2004.23568.x
[4] AKEMI ISHIDA-YAMAMOTO. Decreased Deiminated Keratin K1 in Psoriatic Hyperproliferative Epidermis[J]. Journal of Investigative Dermatology, 2000, 114 4: Pages 701-705. DOI: 10.1046/j.1523-1747.2000.00936.x
[5] AKEMI ISHIDA-YAMAMOTO . Sequential Reorganization of Cornified Cell Keratin Filaments Involving Filaggrin-Mediated Compaction and Keratin 1 Deimination[J]. Journal of Investigative Dermatology, 2002, 118 2: Pages 282-287. DOI: 10.1046/j.0022-202x.2001.01671.x
[6] S. GONIAS M S T Hembrough. Cytokeratin 8 functions as a major plasminogen receptor in select epithelial and carcinoma cells.[J]. Frontiers in Bioscience-Landmark, 2001, 5 1: D1403-11. DOI: 10.2741/gonias
[7] XIAOQIAN ZHANG. Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development[J]. Scientific Reports, 2016, 6 1. DOI: 10.1038/srep38727
[8] HAO QIN . PAD1 promotes epithelial-mesenchymal transition and metastasis in triple-negative breast cancer cells by regulating MEK1-ERK1/2-MMP2 signaling[J]. Cancer letters, 2017, 409: Pages 30-41. DOI: 10.1016/j.canlet.2017.08.019 |
| | PAD1 (human recombinant) Preparation Products And Raw materials |
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