- 2-(diMethylphosphoryl)aniline
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- $5.00 / 1KG
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2024-04-09
- CAS:1197953-47-1
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: g-kg-tons, free sample is available
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| | (2-Aminophenyl)dimethylphosphine Oxide Basic information |
| Product Name: | (2-Aminophenyl)dimethylphosphine Oxide | | Synonyms: | 2-(diMethylphosphoryl)aniline;2-(diMethylphosphoryl)benzenaMine;(2-AMinophenyl)diMethylphosphine oxide;Benzenamine, 2-(dimethylphosphinyl)-;2-(Dimethylphosphinyl)benzenamine;2-(Dimethylphosphinyl)benzeneamine;2-(Dimethylphosphinyl)aniline;2-(diMethylphosphoryl)aniline HCl | | CAS: | 1197953-47-1 | | MF: | C8H12NOP | | MW: | 169.16 | | EINECS: | | | Product Categories: | | | Mol File: | 1197953-47-1.mol |  |
| | (2-Aminophenyl)dimethylphosphine Oxide Chemical Properties |
| Boiling point | 367.5±34.0 °C(Predicted) | | density | 1.11±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 1.10±0.10(Predicted) | | Appearance | Off-white to light yellow Solid | | InChI | InChI=1S/C8H12NOP/c1-11(2,10)8-6-4-3-5-7(8)9/h3-6H,9H2,1-2H3 | | InChIKey | DHHGHQKIKXKQGJ-UHFFFAOYSA-N | | SMILES | C1(N)=CC=CC=C1P(C)(C)=O |
| RIDADR | UN2811 | | HS Code | 2923900090 |
| | (2-Aminophenyl)dimethylphosphine Oxide Usage And Synthesis |
| Uses | (2-Aminophenyl)dimethylphosphine Oxide is mainly used as a raw material or reagent for organic synthesis and can be used to prepare other compounds such as phosphine oxide derivatives and pyrimidine derivatives. | | Synthesis | (2-Aminophenyl)dimethylphosphine Oxide is prepared by the reaction of 2-Iodoaniline and Dimethylphosphine oxide. The specific synthesis steps are as follows:
To a solution of 2-iodoaniline ( 1.0 eq) and dimethylphosphine oxide (1.1 eq) in DMF were added potassium phosphate ( 1.1 eq) and palladium acetate/Xantphos (catalytic). The reaction was stirred at 150 °C for 3 hours and cooled to room temperature. The solvent was evaporated and the residue was worked up with DCM/water. The crude product was purified with a column(EtOAc/MeOH 10: 1 ) to give 1 as a brown solid (80percent yield).
 | | References | [1] Patent: WO2012/151561, 2012, A1. Location in patent: Page/Page column 37
[2] Patent: WO2013/169401, 2013, A1. Location in patent: Page/Page column 41-42
[3] Patent: US2015/225436, 2015, A1. Location in patent: Paragraph 0791-0792
[4] Patent: CN106928275, 2017, A. Location in patent: Paragraph 0097-0099
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 10, p. 4948 - 4964 |
| | (2-Aminophenyl)dimethylphosphine Oxide Preparation Products And Raw materials |
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