2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI)

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2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI) Suppliers list
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2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI) Basic information
Product Name:2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI)
Synonyms:2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI);(3R,4S)-4-[4-chloro-N-(1H-imidazol-2-ylmethyl)anilino]-3-hydroxy-2,2-dimethyl-3,4-dihydrochromene-6-carbonitrile:hydrochloride;BMS-191095 hydrochloride >=98% (HPLC);BMS-191095 hydrochloride;(3R,4S)-4-(((1H-imidazol-2-yl)methyl)(4-chlorophenyl)amino)-3-hydroxy-2,2-dimethylchromane-6-carbonitrile hydrochloride
CAS:166095-95-0
MF:C22H22Cl2N4O2
MW:445.34168
EINECS:
Product Categories:
Mol File:166095-95-0.mol
2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI) Structure
2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI) Chemical Properties
storage temp. room temp
solubility DMSO: 20mg/mL, clear
form powder
color white to beige
InChIKeyTZLMTXNZECPICU-JUDYQFGCSA-N
SMILESCC1(C)OC2=CC=C(C#N)C=C2[C@H](N(CC3=NC=CN3)C4=CC=C(Cl)C=C4)[C@H]1O.[H]Cl
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Skin Irrit. 2
STOT SE 3
MSDS Information
2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI) Usage And Synthesis
UsesBMS-191095 hydrochloride is a mitochondrial KATP channel opener. BMS-191095 hydrochloride can protect the myocardium without causing vasodilation or affecting electrophysiology, by prolonging the contraction time during ischemia, improving contractile function after reperfusion, and reducing lactate dehydrogenase (LDHM) release, thereby exerting its cardioprotective effects[1].
Biological ActivityBMS-191095 is a potent and selective mitochondrial ATP-sensitive K1 channel (KATP) channel opener devoid of peripheral vasodilating activity. BMS-191095 improves postischemic recovery of function and reduced lactate dehydrogenase release in the isolated r at hearts.
References[1] Grover GJ, et al. Pharmacologic profile of the selective mitochondrial-K(ATP) opener BMS-191095 for treatment of acute myocardial ischemia. Cardiovasc Drug Rev. 2002 Summer;20(2):121-36. DOI:10.1111/j.1527-3466.2002.tb00187.x
2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI) Preparation Products And Raw materials
Tag:2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI)(166095-95-0) Related Product Information
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