| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Ellipticine quinone
CAS:73326-98-4
Package:50mg/RMB 13800;25mg/RMB 10600;100mg/RMB 17500
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| Company Name: |
Shanghai meikai technology co., ltd
|
| Tel: |
021-68689288 15300790979 |
| Email: |
info@mkbio.com.cn |
| Products Intro: |
Product Name:5H,6H,11H-pyrido[4,3-b]carbazole-5,11-dione
CAS:73326-98-4
Purity:98% Package:100mg/RMB 2000;500mg/RMB 7000;2g/RMB 18000
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5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione manufacturers
- Ellipticine quinone
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- $1980.00 / 50mg
-
2026-01-04
- CAS:73326-98-4
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione Basic information |
| | 5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione Chemical Properties |
| Melting point | >300 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3)) | | Boiling point | 543.0±40.0 °C(Predicted) | | density | 1.506±0.06 g/cm3(Predicted) | | form | Solid | | pka | 11.81±0.20(Predicted) | | color | Light brown to brown |
| | 5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione Usage And Synthesis |
| Description | Ellipticine quinone, also known as NSC-383230, is a Drp1 inhibitor. rpitor1 and Drpitor1a inhibited the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1. Ellipticine quinone showed greater potency than the current std. Drp1 GTPase inhibitor, mdivi-?1, (IC50 for mitochondrial fragmentation are (0.06, and 10 μM, resp.)?. Ellipticine quinone suppressed lung cancer tumor growth in a mouse xenograft model. Ellipticine quinone also inhibited mitochondrial ROS prodn., prevented mitochondrial fission, and improved right ventricular diastolic dysfunction during IR injury. | | Uses | Drpitor1a is a potent Drp1 inhibitor. Drpitor1a inhibits mitochondrial ROS production, preventes mitochondrial fission, and improves right ventricular diastolic dysfunction during IR (ischemia reperfusion) injury. Drpitor1a has the potential for the research of lung cancer[1][2]. | | References | [1] Wu D, et al. Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury. FASEB J. 2020 Jan;34(1):1447-1464. DOI:10.1096/fj.201901467R
[2] Wu D, et al. Efficacy of Drpitor1a, a Dynamin-Related Protein 1 inhibitor, in Pulmonary Arterial Hypertension. bioRxiv [Preprint]. 2023 Dec 23:2023.12.21.572836. DOI:10.1101/2023.12.21.572836 |
| | 5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione Preparation Products And Raw materials |
| Raw materials | 1H-Indole-3-carboxylic acid, 2-(4-pyridinylcarbonyl)-, ethyl ester-->1H-Indole-3-carboxylic acid, 2-(4-pyridinylcarbonyl)--->5H-Pyrido[4',3':5,6]oxepino[3,2-b]indol-5-one, 6,12-dihydro--->1H-Indole-2-carboxylic acid, 3-(3-pyridinylcarbonyl)-, ethyl ester-->N-(methoxymethyl)-3-indolecarboxaldehyde-->sodiuM 2-(2-aMinophenyl)-2-oxoacetate-->Isatin-->Indole-3-carboxaldehyde-->Indole | | Preparation Products | 5H-Pyrido[3,4-b]carbazole-5,11(10H)-dione |
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