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| | 2-broMo-3-Methyl-pyridine-3-carboxyl acid Basic information |
| | 2-broMo-3-Methyl-pyridine-3-carboxyl acid Chemical Properties |
| Boiling point | 373.9±42.0 °C(Predicted) | | density | 1.692±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 3.42±0.10(Predicted) |
| | 2-broMo-3-Methyl-pyridine-3-carboxyl acid Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 6-bromo-5-methyl-pyridine-2-carboxylic acid from 5-methyl-6-bromo-pyridine-2-carbonitrile was as follows: 6-bromo-5-methyl-pyridine-2-carbonitrile (1.0 g, 5.0 mmol) was dissolved in an aqueous solution of sodium hydroxide (0.3 g, 7 mmol, 20 mL), and the reaction was stirred at 120 °C overnight. Upon completion of the reaction, the reaction mixture was adjusted to pH=3 with acid and subsequently extracted with ethyl acetate (3 x 15 mL). The organic phases were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 6-bromo-5-methyl-pyridine-2-carboxylic acid (0.7 g, 63.8% yield). Mass spectrometry (EI) analysis showed m/e 216.0 [M+H]+. | | References | [1] Patent: US2012/316147, 2012, A1. Location in patent: Page/Page column 52
[2] Patent: WO2012/168350, 2012, A1. Location in patent: Page/Page column 114 |
| | 2-broMo-3-Methyl-pyridine-3-carboxyl acid Preparation Products And Raw materials |
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