- 5-chloro-2,3-diphenylpyrazine
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- $8.00 / 1kg
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2025-09-25
- CAS:41270-66-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | 5-chloro-2,3-diphenylpyrazine Basic information |
| Product Name: | 5-chloro-2,3-diphenylpyrazine | | Synonyms: | 2-Chloro-5,6-diphenylpyrazine;Pyrazine, 5-chloro-2,3-diphenyl-;Selexipag Impurity 31;chloro-2,3-diphenylpyrazine
(Selexipag Intermediate);5-chlChemicalbookoro-2,3-diphenylpyrazine;5-chloro-2,3-diphenylpyrazine;5-Chloro-2,3-diphenylpyrazine (Selexipag Impurity) | | CAS: | 41270-66-0 | | MF: | C16H11ClN2 | | MW: | 266.72 | | EINECS: | 813-797-2 | | Product Categories: | Selexipag intermediate | | Mol File: | 41270-66-0.mol |  |
| | 5-chloro-2,3-diphenylpyrazine Chemical Properties |
| Melting point | 126-128℃ (methanol ) | | Boiling point | 145°C/0.001mmHg(lit.) | | density | 1+-.0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, sealed storage, away from moisture | | form | powder to crystal | | pka | -2.16±0.10(Predicted) | | color | White to Orange to Green | | InChI | InChI=1S/C16H11ClN2/c17-14-11-18-15(12-7-3-1-4-8-12)16(19-14)13-9-5-2-6-10-13/h1-11H | | InChIKey | VUGNCPVAXWZTOL-UHFFFAOYSA-N | | SMILES | C1(C2=CC=CC=C2)=NC=C(Cl)N=C1C1=CC=CC=C1 | | CAS DataBase Reference | 41270-66-0 |
| | 5-chloro-2,3-diphenylpyrazine Usage And Synthesis |
| Uses | 2-Chloro-5,6-diphenylpyrazine is a diphenylpyrazine derivative used in a study to determine a novel class of prostacyclin receptor agonists. | | Synthesis |
50 gm of 2-hydroxy-5,6-diphenylpyrazine obtained was treated with 250 ml of POCI3 and then heated the reaction mixture at 100-110 °C with stirring for 5-6 hrs. The reaction mixture was cooled to room temperature and poured in 1000 ml of ice water at 0-5 °C and maintained with stirring for 60 minutes. The solid obtained was filtered, washed with water and dried to obtain 41.3 gm of 5-chloro-2,3-diphenylpyrazine. Yield: 77.00 percent.
| | References | [1] Journal of the American Chemical Society, 1952, vol. 74, p. 1580,1582
[2] Patent: WO2017/168401, 2017, A1. Location in patent: Page/Page column 12 |
| | 5-chloro-2,3-diphenylpyrazine Preparation Products And Raw materials |
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