4-Bromo-2-iodobenzaldehyde manufacturers
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| | 4-Bromo-2-iodobenzaldehyde Basic information |
| Product Name: | 4-Bromo-2-iodobenzaldehyde | | Synonyms: | 4-Bromo-2-iodobenzaldehyde;4-Bromo-2-iodobenzaldehyde97%;Benzaldehyde, 4-bromo-2-iodo-;4-Bromo-2-iodobenzaldehyde 97%;2-IODO-4-BROMO BENZALDEHYDE | | CAS: | 1261470-87-4 | | MF: | C7H4BrIO | | MW: | 310.91 | | EINECS: | | | Product Categories: | | | Mol File: | 1261470-87-4.mol |  |
| | 4-Bromo-2-iodobenzaldehyde Chemical Properties |
| Boiling point | 323.2±37.0 °C(Predicted) | | density | 2.231±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | powder | | color | Off white to faint cream | | InChI | InChI=1S/C7H4BrIO/c8-6-2-1-5(4-10)7(9)3-6/h1-4H | | InChIKey | JFFYPBIPKMTEEQ-UHFFFAOYSA-N | | SMILES | C(=O)C1=CC=C(Br)C=C1I |
| | 4-Bromo-2-iodobenzaldehyde Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 4-bromo-2-iodobenzaldehyde (17b) from 4-bromo-1-(bromomethyl)-2-iodobenzene: A solution of N-methylmorpholine-N-oxide (2.81 g, 23.2 mmol) and 4A molecular sieves (19 g) in acetonitrile (60 mL) was added to a dry 250 mL Schlenk flask under nitrogen protection and cooled to 0 °C. This was followed by rapid addition of benzyl bromide 15b (2.9 g, 7.7 mmol). The reaction mixture was kept at 0 °C for 2 h and then slowly warmed up to room temperature. Upon completion of the reaction, it was filtered through a short column of silica gel (SiO2:hexane) to afford the off-white solid product 17b (2.15 g, 6.92 mmol, 90% yield). The product was characterized as follows: 1H-NMR (400 MHz, CDCl3) δ: 9.99 (s, 1H), 8.13 (d, 1H, J = 0.8 Hz), 7.73 (dd, 1H, J = 8.3, 0.8 Hz), 7.61 (dd, 1H, J = 8.3, 0.8 Hz); 13C-NMR (100 MHz, CDCl3) δ: 194.7, 142.8, 134.1, 132.3, 131.1, 130.2, 100.9; HRMS (EI) m/z calculated value of C7H4BrIO [M]+: 309.8490, measured value: 309.8489. | | References | [1] Journal of Organic Chemistry, 2011, vol. 76, # 7, p. 2227 - 2239
[2] Synthesis, 2011, # 15, p. 2387 - 2391
[3] Patent: WO2011/127383, 2011, A2. Location in patent: Page/Page column 75 |
| | 4-Bromo-2-iodobenzaldehyde Preparation Products And Raw materials |
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