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N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride manufacturers
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| | N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride Basic information |
| | N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: ≥25mg/mL | | form | powder | | color | white to tan | | InChIKey | PFIWYJNBKGCVFM-UHFFFAOYSA-N | | SMILES | Cl.Clc1cccc(N2CCN(CCCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride Usage And Synthesis |
| Uses | NGB 2904 Hydrochloride is a dopamine D3 receptor antagonist that inhibits cocaine’s rewarding effects and cocaine-induced reinstatement of drug seeking behavior in rats. | | Biological Activity | Inhibition of dopamine D3 receptor function by NGB 2904 increases spontaneous locomotor activity in rodents.', 'NGB 2904 is a potent and selective dopamine D3 receptor antagonist with a D3/D2 ratio of 800 for r at and high binding affinity (1.4 nM) at the hD3 receptor with 150-fold selectivity for primate D3 receptors over primate D2L receptors. It attenuates the rewarding effects of cocaine and methamphetamine. | | in vivo | NGB 2904 (26 μg/kg; a single s.c.) enhances amphetamine (26 mg/kg)-stimulated locomotion in wild-type mice[3].
NGB 2904 (0.026 μg-1 mg/kg; a single s.c. or once daily for 7 d) stimulates spontaneous locomotion in wild-type mice[3]. | | IC 50 | D3 Receptor: 1.4 (Ki) | | storage | Desiccate at +4°C |
| | N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride Preparation Products And Raw materials |
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