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MLS-0315848 hydrochloride manufacturers
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| | MLS-0315848 hydrochloride Basic information |
| Product Name: | MLS-0315848 hydrochloride | | Synonyms: | 1-(3,4-Dihydroxyphenyl)-2-(2-ethyl-1H-imidazol-1-yl)-Ethanone hydrochloride;CID-25067483 hydrochloride;ML095 hydrochloride;MLS-0315848 hydrochloride;1-(3,4-Dihydroxyphenyl)-2-(3-ethyl-1H-pyrazol-1-yl)ethanone Hydrochloride;MLS-0315848 hcl;ML095 HCL;CID-25067483,ML-095,ML 095,ML095 hydrochloride,ML095,inhibit,ML 095 hydrochloride,CID25067483,Inhibitor,CID 25067483 | | CAS: | 1135318-57-8 | | MF: | C13H14N2O3.ClH | | MW: | 282.72 | | EINECS: | | | Product Categories: | | | Mol File: | 1135318-57-8.mol |  |
| | MLS-0315848 hydrochloride Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: soluble5mg/mL, clear | | form | powder | | color | white to beige |
| | MLS-0315848 hydrochloride Usage And Synthesis |
| Uses | 1-(3,4-Dihydroxyphenyl)-2-(3-ethyl-1H-pyrazol-1-yl)ethanone Hydrochloride is a biochemical inhibitor of placental alkaline phosphatase (PLAP) and is used to elucidate the key biological functions and natural substrates of human PLAP. | | Biological Activity | ml-095 (hydrochloride) is a specific plap inhibitor [1].alkaline phosphatases are hydrolase enzymes responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. there are three isozymes of alkaline phosphatases: placental alkaline phosphatase (plap), intestinal alkaline phosphatase (iap), and tissue non-specific alkaline phosphatase (tnap). placental alkaline phosphatase (plap) is highly expressed in primate placental tissue and the biological function is still unknown. however, plap-like enzymes are detected in serum of patients with primary testicular tumors, in particular seminoma and other cancers [1].ml-095 (cid-25067483) is a biochemical inhibitor of plap and will be useful to elucidate the key biological functions and natural substrates of human plap. ml095 is a specific plap inhibitor and inhibited plap, tnap and iap with ic50 values of 2.1, >100 and 53 μm, respectively. ml095 exhibited greater than 25-fold selectivity over tissue non-specific alkaline phosphatase (tnap) and intestinal alkaline phosphatase (iap) [1]. | | references | [1]. lanier m, cashman j, sergienko e, et al. placental alkaline phosphatase (plap) luminescent hts assay - probe 2. |
| | MLS-0315848 hydrochloride Preparation Products And Raw materials |
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