- 3-Indoleacetamide
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- $10.00 / 1KG
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2026-03-20
- CAS:879-37-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- Indole-3-acetamide
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- $31.00 / 500mg
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2026-03-13
- CAS:879-37-8
- Min. Order:
- Purity: 99.87%
- Supply Ability: 10g
- Indole-3-acetamide
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- $122.00 / 1KG
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2025-09-25
- CAS:879-37-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | 3-Indoleacetamide Basic information |
| | 3-Indoleacetamide Chemical Properties |
| Melting point | 148-150 °C(lit.) | | Boiling point | 469.7±28.0 °C(Predicted) | | density | 1.285±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMSO (Slightly) | | pka | 16.37±0.40(Predicted) | | form | Solid | | color | White to Off-White | | InChI | InChI=1S/C10H10N2O/c11-10(13)5-7-6-12-9-4-2-1-3-8(7)9/h1-4,6,12H,5H2,(H2,11,13) | | InChIKey | ZOAMBXDOGPRZLP-UHFFFAOYSA-N | | SMILES | N1C2=C(C=CC=C2)C(CC(N)=O)=C1 | | CAS DataBase Reference | 879-37-8(CAS DataBase Reference) | | NIST Chemistry Reference | 3-Indoleacetamide(879-37-8) |
| Hazard Codes | Xi | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids |
| | 3-Indoleacetamide Usage And Synthesis |
| Chemical Properties | White to Orange to Green powder to crystal | | Uses | Indole-3-acetamide was used in the synthesis of [5.5.6.6]diazafenestrane skeleton and indole-3-acetic acid.
Reactant for the synthesis of:
PET agent for imaging of protein kinase C
A potential agent against Prion Disease
Protein kinase C (PKC) inhibitor bisindolylmaleimide IV
Glycogen synthase kinase-3 (GSK-3) inhibitors
Inhibitors of CaMKIId
A VEGF inhibitor
JAK3 inhibitors
Inhibitors of NAD+-Dependent Histone Deacetylases
Inhibitors of human adipocyte fatty acid-binding protein
Cyclin-dependent kinase inhibitors | | Definition | ChEBI: Indole-3-acetamide is a member of the class of indoles that is acetamide substituted by a 1H-indol-3-yl group at position 2. It is an intermediate in the production of plant hormone indole acetic acid (IAA). It has a role as a fungal metabolite, a bacterial metabolite and a plant metabolite. It is a N-acylammonia, a monocarboxylic acid amide and a member of indoles. It is functionally related to an acetamide. | | General Description | Indole-3-acetamide is an auxin precursor. | | Biological Activity | Indole-3-acetamide is a biosynthesis intermediate of indole-3-acetic acid. Indole-3-acetic acid is the most common natural plant growth hormone of the auxin class. | | Synthesis | The general procedure for the synthesis of 3-indoleacetamide from indole-3-acetonitrile was as follows: the reaction was carried out in a 100-mL stainless steel autoclave. Indole-3-acetonitrile (0.10 g, 1.00 mmol) was added to a mixture of ethylenediamine (0.12 g, 2.00 mmol), CoCl2-H2O (0.24 g, 1.00 mmol), and Zn (0.07 g, 1.00 mmol) and the mixture was transferred to the autoclave. For reactions to be performed in solvent, an additional 5 mL of solvent was added. The autoclave was pressurized to 5.00 atm using O2. the reaction mixture was stirred in a preheated 120°C oil bath for 12 hr. Upon completion of the reaction, the mixture was cooled to room temperature and the product was purified by silica gel column chromatography using a solvent mixture of n-hexane and CH2Cl2 (1:1) as eluent to give the final 3-indoleacetamide in 88% yield. | | References | [1] Tetrahedron, 1989, vol. 45, # 5, p. 1347 - 1354
[2] Research on Chemical Intermediates, 2015, vol. 41, # 8, p. 5071 - 5078
[3] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1980, vol. 16, # 5, p. 501 - 506
[4] Khimiya Geterotsiklicheskikh Soedinenii, 1980, # 5, p. 645 - 650 |
| | 3-Indoleacetamide Preparation Products And Raw materials |
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