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| | cAMP-dependent protein kinase type I-alpha regulatory subunit Basic information | | Description Source |
| Product Name: | cAMP-dependent protein kinase type I-alpha regulatory subunit | | Synonyms: | Anti-PKR1, N-Terminal antibody produced in rabbit;Anti-KAP0, C-Terminal antibody produced in rabbit;ANTI-PROTEIN KINASE A REGULATORY SUBUNIT I ALPHA(N-TERMINAL) antibody produced in rabbit;PKR1;PRKAR1;TSE1;cAMP-dependent protein kinase type I-alpha regulatory subunit;PRKAR1A | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![cAMP-dependent protein kinase type I-alpha regulatory subunit Structure]() |
| | cAMP-dependent protein kinase type I-alpha regulatory subunit Chemical Properties |
| Hazard Codes | T | | Risk Statements | 61 | | Safety Statements | 53-45 |
| | cAMP-dependent protein kinase type I-alpha regulatory subunit Usage And Synthesis |
| Description | cAMP-dependent PKA is an ubiquitous serine/theonine protein kinase present in a variety of tissues (e.g. brain, skeletal muscle, heart). The intracellular cAMP level regulates cellular responses by altering the interaction between the catatytic C and regulatory R subunits of PKA. The inactive tetrameric PKA holoenzyme R2C2 is activated when cAMP binds to R2, which dissociates the tetramer to R2 cAMP 4 and two active catalytic subunits. Free Catalytic subunits of PKA can phosphorylate a wide variety of intracellular target proteins. In response to hormone- induced high cAMP levels, PKA phosphorylates glycogen synthetase (inhibition of the enzyme activity) and phosphorylase kinase to block glycogen synthesis. Different isoforms of catalytic and regulatory subunits suggest specific functions. The recombinant PKA regulatory subunit I a is a dimeric 90kDa protein. | | Source | Escherichia Coli |
| | cAMP-dependent protein kinase type I-alpha regulatory subunit Preparation Products And Raw materials |
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