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Sigma-Aldrich |
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Biolab Reagents |
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ACROBiosystems |
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| Product Name: | RSPO1 | | Synonyms: | Monoclonal Anti-RSPO1 antibody produced in mouse;CRISTIN3;FLJ40906;RSPO1;R-SPONDIN-1 human;Roof plate-specific spondin-1;RSPONDIN;HRspo1 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![RSPO1 Structure]() |
| | RSPO1 Chemical Properties |
| storage temp. | -20°C | | form | lyophilized | | color | white | | biological source | human |
| WGK Germany | 3 | | Storage Class | 10 - Combustible liquids |
| | RSPO1 Usage And Synthesis |
| Uses | R-Spondin-1 (Rspo-1) belongs to the (Rspo) family of Wnt modulators. Currently, the (Rspo) family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. Rspo-1 is expressed in certain areas of the developing central nervous system, as well as in adrenal glands, ovary, testis, thyroid, and trachea. Recombinant human R-Spondin-1 is a 26.7kDa protein consisting of 243 amino acid residues. Due to glycosylation, R-Spondin-1 migrates at an apparent molecular weight of approximately 40.0kDa by SDS PAGE analysis under reducing conditions. | | General Description | R-Spondin-1 (Rspo-1) belongs to the (Rspo) family of Wnt modulators. Currently, the (Rspo) family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. Rspo-1 is expressed in certain areas of the developing central nervous system, as well as in adrenal glands, ovary, testis, thyroid, and trachea. Recombinant human R-Spondin-1 is a 26.7kDa protein consisting of 243 amino acid residues. Due to glycosylation, R-Spondin-1 migrates at an apparent molecular weight of approximately 40.0kDa by SDS PAGE analysis under reducing conditions. | | Biochem/physiol Actions | Rspo (R-Spondin) can interact with the Frizzled/LRP6 (LDL receptor related protein 6) receptor complex in a manner that stimulates the Wnt/beta-catenin signaling pathway. Disruption of Rspo-1 gene causes recessive syndrome with XX sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. Rspo-1 is also associated with radioresistance of tumor cells. |
| | RSPO1 Preparation Products And Raw materials |
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