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| | METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE Basic information |
| Product Name: | METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE | | Synonyms: | METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE;4-METHOXYCARBONYL-BENZYLAMINE HYDROCHLORIDE;4-(AMINOMETHYL)BENZOIC ACID METHYL ESTER HYDROCHLORIDE;BUTTPARK 33\11-77;Methyl4-(aminomethyl)benzoateHCl;Methyl 4-(aminomethyl)benzoate hydrochloride,97%;4-(Aminomethyl)benzoate monohydrochloride;Benzoic acid, 4-(aminomethyl)-, methyl ester, hydrochloride (1:1) | | CAS: | 6232-11-7 | | MF: | C9H12ClNO2 | | MW: | 201.65 | | EINECS: | | | Product Categories: | DY-25G;C8 to C9;Carbonyl Compounds;Esters | | Mol File: | 6232-11-7.mol |  |
| | METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE Chemical Properties |
| Melting point | 243 °C (dec.)(lit.) | | storage temp. | Inert atmosphere,Room Temperature | | form | Crystalline Powder | | color | White | | InChI | InChI=1S/C9H11NO2.ClH/c1-12-9(11)8-4-2-7(6-10)3-5-8;/h2-5H,6,10H2,1H3;1H | | InChIKey | GIZCKBSSWNIUMZ-UHFFFAOYSA-N | | SMILES | C(OC)(=O)C1=CC=C(CN)C=C1.[H]Cl | | CAS DataBase Reference | 6232-11-7 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29224999 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | White crystalline powder | | Uses | Methyl 4-(aminomethyl)benzoate hydrochloride may be used in the preparation of methyl 4-((3-butyl-3-phenylureido)methyl)benzoate. | | General Description | Methyl 4-(aminomethyl)benzoate hydrochloride is an amino acid ester hydrochloride. Its synthesis by esterification reaction has been reported. It plays a role during the preparation of a novel hepatitis C virus (HCV) helicase inhibitor. | | Synthesis | 4-(Aminomethyl)benzoic acid (302 mg, 2.00 mmol) was dissolved in methanol (30 mL) and thionyl chloride (1.16 mL, 16.0 mmol) was added slowly and dropwise at room temperature. The reaction mixture was stirred at room temperature overnight. Subsequently, the solvent was removed by distillation under reduced pressure to afford the target product, methyl 4-aminomethylbenzoate hydrochloride (15d), as a colorless solid in 390 mg (97%) yield with a melting point of 234 °C. The molecular formula was C9H12ClNO2 (molecular weight 201.7). Thin layer chromatography (TLC) analysis showed an Rf value of 0.22 (Expanding agent: ethyl acetate/1% diethylmethylamine, detection wavelength 254 nm). Nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 400 MHz, DMSO-D6) showed chemical shifts δ [ppm]: 3.86 (single peak, 3H, CO2CH3), 4.10 (single peak, 2H, H3NCH2), 7.63-7.67 (multiple peaks, 2H, 3-HB, 5-HB), 7.96-8.01 (multiple peaks, 2H, 2-HB, 6 -HB), 8.61 (broad peaks, 3H, NH3). Nuclear magnetic resonance carbon spectra (13C NMR, 101 MHz, DMSO-D6) showed chemical shifts δ [ppm]: 41.7 (1C, H3NCH2), 52.2 (1C, CO2CH3), 129.2 (2C, C-3B, C-5B), 129.3 (2C, C-2B, C-6B), 129.5 (1C, C-1B). 139.4 (1C, C-4B), 165.9 (1C, CO2CH3). Fourier transform infrared spectroscopy (FT-IR) showed absorption peaks ν [cm-1]: 2963 (NH3+), 2878 (C-H aliphatic), 2573 (NH3+), 1678 (C=O), 1597, 1578, 1477 (C=C aromatic), and 864 (aromatic ring out-of-plane bending vibration). High resolution mass spectrometry (HRMS, APCI) showed m/z = 166.0865 (calculated value C9H12NO2 [M+H]+: 166.0863). High performance liquid chromatography (HPLC) analysis showed retention time tR = 6.4 min and purity 99.9%. | | References | [1] Angewandte Chemie - International Edition, 2011, vol. 50, # 21, p. 4872 - 4875
[2] European Journal of Medicinal Chemistry, 2017, vol. 129, p. 124 - 134
[3] Patent: US5585381, 1996, A |
| | METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE Preparation Products And Raw materials |
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