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| | 2,2-Difluoropropionic acid Chemical Properties |
| Melting point | 38-45 °C | | Boiling point | 25-30 °C/5 mmHg | | density | 1.316±0.06 g/cm3(Predicted) | | Fp | 25-30°C/5mm | | storage temp. | Inert atmosphere,Room Temperature | | pka | 1.34±0.10(Predicted) | | form | powder to crystal | | color | White to Almost white | | InChI | InChI=1S/C3H4F2O2/c1-3(4,5)2(6)7/h1H3,(H,6,7) | | InChIKey | PMWGIVRHUIAIII-UHFFFAOYSA-N | | SMILES | C(O)(=O)C(F)(F)C | | CAS DataBase Reference | 373-96-6(CAS DataBase Reference) |
| Hazard Codes | Xi,C | | Risk Statements | 34-36 | | Safety Statements | 26-36/37/39 | | RIDADR | 3261 | | WGK Germany | 3 | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29159000 |
| | 2,2-Difluoropropionic acid Usage And Synthesis |
| Uses | 2,2-Difluoropropionic acid is a useful research chemical. | | Application | 2,2-Difluoropropionic acid is mainly used in biochemical research. | | Chemical Properties | White powder | | Synthesis | The general procedure for synthesizing 2,2-difluoropropionic acid from ethyl 2,2-difluoropropionate was as follows: referring to Example G38, ethyl 2,2-difluoropropionate (1.2 g, 8.8 mmol) was dissolved in ethanol (26 mL), followed by the slow addition of 2N aqueous sodium hydroxide solution (26 mL). The reaction mixture was stirred at 0 °C, then gradually warmed to room temperature and continued stirring for 14 hours. Upon completion of the reaction, the reaction mixture was acidified to pH < 7 with 2N hydrochloric acid and then extracted with ether. The organic phases were combined, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to give 2,2-difluoropropionic acid (0.90 g, 92% yield). The product was an oil with the following 1H-NMR (CDCl3) data: δ 1.85 (3H, t, J = 19.0 Hz), 6.21 (1H, br s). | | References | [1] Patent: EP1402900, 2004, A1
[2] Patent: US2004/53973, 2004, A1
[3] Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, p. 1260 - 1263
[4] Zhurnal Organicheskoi Khimii, 1981, vol. 17, # 7, p. 1417 - 1420
[5] Journal of Organic Chemistry USSR (English Translation), 1982, vol. 18, p. 1597 - 1601 |
| | 2,2-Difluoropropionic acid Preparation Products And Raw materials |
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