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METHYL 4-AMINO-3-CHLOROBENZOATE

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Products Intro: Product Name:methyl 4-amino-3-chlorobenzoate
CAS:84228-44-4
Purity:98%(Min,GC) Package:100g;1kg;5kg,10kg,25kg,50kg
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Products Intro: Product Name:METHYL 4-AMINO-3-CHLOROBENZOATE
CAS:84228-44-4
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Products Intro: Product Name:Methyl 4-amino-3-chlorobenzoate
CAS:84228-44-4
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-61774
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Products Intro: Product Name:Methyl4-amino-3-chlorobenzoate
CAS:84228-44-4
Purity:0.98 Package:1g;5g;25g;100;500g
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Purity:0.99 Package:1kg,25kg

METHYL 4-AMINO-3-CHLOROBENZOATE manufacturers
METHYL 4-AMINO-3-CHLOROBENZOATE Basic information
Product Name:METHYL 4-AMINO-3-CHLOROBENZOATE
Synonyms:TIMTEC-BB SBB003712;METHYL 4-AMINO-3-CHLOROBENZOATE;Methyl4-amino-3-chlorobenzoate98%;AKOS BB-3098;4-AMINO-3-CHLORO-BENZOIC ACID METHYL ESTER;2-Chloro-4-(methoxycarbonyl)aniline;Methyl 4-aMino-3-chlorobenzoate, 97% 5GR;Benzoic acid, 4-aMino-3-chloro-, Methyl ester
CAS:84228-44-4
MF:C8H8ClNO2
MW:185.61
EINECS:
Product Categories:Aromatic Esters;C8 to C9;Carbonyl Compounds;Esters
Mol File:84228-44-4.mol
METHYL 4-AMINO-3-CHLOROBENZOATE Structure
METHYL 4-AMINO-3-CHLOROBENZOATE Chemical Properties
Melting point 107-111 °C
Boiling point 321.6±22.0 °C(Predicted)
density 1.2797 (rough estimate)
refractive index 1.5560 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Crystalline Powder
pka0.52±0.10(Predicted)
color Beige-brown
InChI1S/C8H8ClNO2/c1-12-8(11)5-2-3-7(10)6(9)4-5/h2-4H,10H2,1H3
InChIKeyWKVJBYKFGNVWLM-UHFFFAOYSA-N
SMILESCOC(=O)c1ccc(N)c(Cl)c1
CAS DataBase Reference84228-44-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22
Safety Statements 36/37
WGK Germany 2
Hazard Note Irritant
HS Code 29224985
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
METHYL 4-AMINO-3-CHLOROBENZOATE Usage And Synthesis
Chemical Propertiesbeige-brown crystals or crystalline powder
Synthesis
Methanol

67-56-1

4-Amino-3-chlorobenzoic acid

2486-71-7

METHYL 4-AMINO-3-CHLOROBENZOATE

84228-44-4

Concentrated sulfuric acid (2.00 mL) was added slowly and dropwise to a stirred solution of 3-chloro-4-aminobenzoic acid (2.00 g, 11.7 mmol) in methanol (20.0 mL) at 0 °C. The reaction mixture was warmed to 80 °C and kept stirring for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure. The concentrated residue was diluted with saturated aqueous sodium bicarbonate and extracted with ethyl acetate (2 x 50 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give methyl 4-amino-3-chlorobenzoate (2.10 g, 97% yield). The product was confirmed by NMR hydrogen spectroscopy (400 MHz, DMSO-d6): δ 7.70 (d, J = 1.6Hz, 1H), 7.58 (dd, J = 8.4, 2.0Hz, 1H), 6.77 (d, J = 8.8Hz, 1H), 6.24 (s, 2H), 3.73 (s, 3H).

References[1] Patent: WO2011/128251, 2011, A1. Location in patent: Page/Page column 203
[2] Patent: US2011/257151, 2011, A1. Location in patent: Page/Page column 75
[3] Patent: WO2018/157190, 2018, A1. Location in patent: Paragraph 0337
[4] Journal of Cellular Biochemistry, 2017, vol. 118, # 8, p. 2420 - 2429
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 666 - 680
METHYL 4-AMINO-3-CHLOROBENZOATE Preparation Products And Raw materials
Raw materials4-Amino-3-chlorobenzoic acid-->4-Amino-3-chlorobenzonitrile-->Methyl 4-aminobenzoate-->Methanol-->Chloromethane-->2,2-Dimethoxypropane
Preparation ProductsMETHYL-4-BROMO-3-CHLOROBENZOATE
Tag:METHYL 4-AMINO-3-CHLOROBENZOATE(84228-44-4) Related Product Information
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