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3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile manufacturers
- NS9283
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- $38.00
-
2026-07-15
- CAS:913830-15-6
- Purity: 99.12%
- Supply Ability: 10g
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| | 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Basic information |
| Product Name: | 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile | | Synonyms: | 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile;NS 9283;3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile;NS 9283;NS-9283;NS9283;NS-9283;NS9283;Benzonitrile, 3-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]-;NS9283,Inhibitor,Nicotinic acetylcholine receptors,nAChR,inhibit;NS9283, 10 mM in DMSO | | CAS: | 913830-15-6 | | MF: | C14H8N4O | | MW: | 248.24 | | EINECS: | | | Product Categories: | | | Mol File: | 913830-15-6.mol |  |
| | 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Chemical Properties |
| Boiling point | 469.9±55.0 °C(Predicted) | | density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 3 mg/ml; Ethanol: Partially soluble | | form | A crystalline solid | | pka | 1.40±0.12(Predicted) | | color | White to off-white |
| | 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Usage And Synthesis |
| Description | NS 9283 is a positive allosteric modulator of α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs) that potentiates ACh-induced currents in HEK293 cells expressing human α4β2 subunit-containing nAChRs (EC50 = 4 μM). In vivo, NS 9283 potentiates ABT-594 analgesic efficacy in rat models of carrageenan-induced thermal hyperalgesia, paw skin incision post-operative pain, and monoiodoacetate-induced osteoarthritis. It reduces nicotine, but not sucrose, self-administration and reinstatement in rats when administered at a dose of 3.5 mg/kg. | | Uses | NS 9283 is a positive allosteric modulator of α4β2 receptor affecting the potency of acetylcholine (Ach) related events. This has been linked to affect on everyday brain function including cognitive function and pain alleviation. | | storage | Store at +4°C | | References | [1] M GRUPE. Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (α4)3(β2)2 nicotinic ACh receptors[J]. British Journal of Pharmacology, 2012, 168 8: 2000-2010. DOI: 10.1111/bph.12095
[2] CHANG Z. ZHU. Potentiation of analgesic efficacy but not side effects: Co-administration of an α4β2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats[J]. Biochemical pharmacology, 2011, 82 8: Pages 967-976. DOI: 10.1016/j.bcp.2011.05.007
[3] J. MAURER H S K Sandager‐Nielsen. Attenuation of nicotine taking and seeking in rats by the stoichiometry-selective alpha4beta2 nicotinic acetylcholine receptor positive allosteric modulator NS9283[J]. Psychopharmacology, 2016, 234 1: 475-484. DOI: 10.1007/s00213-016-4475-7 |
| | 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Preparation Products And Raw materials |
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