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| | Azido-PEG3-PFP ester Basic information |
| Product Name: | Azido-PEG3-PFP ester | | Synonyms: | perfluorophenyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate;N3-PEG3-C2-PFP ester;Azido-PEG3-PFP ester;N3-PEG3-PFP;N3-PEG3-PFP ESTER;Azido-PEG3-PFP;N3-PEG3-CH2CH2COOPFP;N3-PEG3-OPFP | | CAS: | 1807530-07-9 | | MF: | C15H16F5N3O5 | | MW: | 413.3 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1807530-07-9.mol |  |
| | Azido-PEG3-PFP ester Chemical Properties |
| solubility | Soluble in DMSO, DCM, DMF |
| | Azido-PEG3-PFP ester Usage And Synthesis |
| Description | Azido-PEG3-PFP ester is a PEG reagent consistig of an azide and PFP ester moities. The azide is reactive with copper-catalyzed Click Chemistry reactions with propargyl, copper-free click chemistry with DBCO and BCN. The PFP ester is amine-reactive and is less susceptible toward hydrolysis compared to NHS ester. | | Uses | N3-PEG3-C2-PFP ester is a nonclaevable 3-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-C2-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | Non-cleavable Linker |
| | Azido-PEG3-PFP ester Preparation Products And Raw materials |
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