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| | Hydroxy-PEG6-CH2CO2tBu Basic information |
| Product Name: | Hydroxy-PEG6-CH2CO2tBu | | Synonyms: | Hydroxy-PEG6-CH2CO2tBu;Hydroxy-PEG6-CH2COOtBu;tert-butyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosanoate;OH-PEG6-CH2COOtBu;Hydroxy-PEG6-t-butyl acetate;Hydroxy-PEG6-CH2-Boc;3,6,9,12,15,18-Hexaoxaeicosanoic acid, 20-hydroxy-, 1,1-dimethylethyl ester;HO-PEG6-CH2COOtBu/3,6,9,12,15,18-Hexaoxaeicosanoic acid, 20-hydroxy-, 1,1-dimethylethyl ester | | CAS: | 297162-47-1 | | MF: | C18H36O9 | | MW: | 396.47 | | EINECS: | | | Product Categories: | peg | | Mol File: | 297162-47-1.mol |  |
| | Hydroxy-PEG6-CH2CO2tBu Chemical Properties |
| Boiling point | 469.5±40.0 °C(Predicted) | | density | 1.086±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | form | Liquid | | pka | 14.36±0.10(Predicted) | | color | Colorless to light yellow |
| | Hydroxy-PEG6-CH2CO2tBu Usage And Synthesis |
| Description | Hydroxy-PEG6-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | Hydroxy-PEG6-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Hydroxy-PEG6-CH2CO2tBu Preparation Products And Raw materials |
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